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SARC Developmental Therapeutics

SARC Developmental Therapeutics . SARC Developmental Therapeutics Committee Update Chand Khanna Chawla /Rosenfeld Developmental Therapeutics Symposium “ Open Science: Biology to Therapy”. SARC-DTC Members. Chand Khanna, DVM, PhD (NCI) Chair Poul Sorenson, MD, PhD (UBC/BC Cancer Agency)

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SARC Developmental Therapeutics

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  1. SARC Developmental Therapeutics SARC Developmental Therapeutics Committee Update Chand KhannaChawla/Rosenfeld Developmental Therapeutics Symposium“Open Science: Biology to Therapy”

  2. SARC-DTC Members • Chand Khanna, DVM, PhD (NCI) Chair • Poul Sorenson, MD, PhD (UBC/BC Cancer Agency) • Raphael Pollock, MD, PhD (MD Anderson) • Kapil Dhingra, MD (KAPital Consulting) • Jeffrey Trent, PhD (Tgen) • David Kirsch, MD, PhD (Duke University) • Peter Houghton, PhD (Ohio State University) • *Shreyaskumar Patel, MD (MD Anderson) • *Denise Reinke, MS, NP (SARC) *Ex Officio

  3. SARC Developmental Therapeutics Committee (DTC To establish an integrated and facile SARC effort closely aligned with the interests of pharmaceutical industry that can provide preclinical and translational data in sarcoma

  4. Investigative Centers Providing SARC-DTC Services Sponsoring Pharmaceutical Partner SARC-DTC Preclinical and Translational Study Report SARC-DTC Preclinical and Translational Infrastructure SARC – Development Therapeutics Committee Investigative Centers engaged by SARC-DTC through Master Services Agreement SARC-DTC work scope managed through a research contract with Sponsors Investigative Centers defined through SARC-DTC

  5. Investigative Centers Providing SARC-DTC Services SARC-DTC Preclinical and Translational Infrastructure SARC – Development Therapeutics Committee Investigative Centers engaged by SARC-DTC through Master Services Agreement • Current Investigative Center Portfolio • >50 Sarcoma Cell Lines • >30 Sarcoma Xenografts • Sarcoma tissues • Frozen tissues • Sarcoma Tissue Arrays • Genomics (SARComics Portal) Investigative Centers defined through SARC-DTC

  6. SARC-DTC Preclinical and Translational Infrastructure • Expansion of drug opportunities/assets for SARC clinical development through the development of preclinical and translational data in sarcoma • Prioritization of SARC developmental path • Opportunity to inform phase 1 and phase 2 transitions within SARC clinical development path • Please help spread the word to interested parties of the opportunities to generate preclinical data in sarcoma through SARC

  7. SARC-Omics Portal • To provide sarcoma investigators a consolidated portal for curation and viewing of “omics” data. • To be developed through a collaboration of TGEN and SARC • Screen shots expected at the SARC/CTOS 2013 in a matter of minutes…

  8. Chawla/Rosenfeld Developmental Therapeutics Symposium SARC Developmental Therapeutics Committee Update Chand KhannaChawla/Rosenfeld Developmental Therapeutics Symposium

  9. Chawla Rosenfeld Developmental Therapeutics Symposium Open Science: Biology to Therapy A Case for Open-Source Drug Discovery – J. Bradner Anti-angiogenic activity of JQ1 in Sarcomas – H. Bid The Sarcoma Data Portal: Making High Content Sarcoma Datasets Available For All Users – J. Keats Discussion (20 min)

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