Fig 4

1. Fig 4 MCF7-AROM1 G1 phase BT474-AROM3 G1 phase p=0.01 p=0.01 p=0.02 p= 0.1 p=0.09 A AND AND DCC RAD AND +LET RAD DCC AND+ RAD AND +LET+RAD AND +LET AND+ RAD AND+ 4-OHTam+RAD AND AND AND +LET+RAD AND+4-OHTam AND+ 4-OHTam+RAD AND+4-OHTam DCC DCC RAD RAD AND +LET AND +LET AND+ RAD AND+ RAD AND +LET+RAD AND +LET+RAD AND+ 4-OHTam+RAD AND+ 4-OHTam+RAD AND+4-OHTam AND+4-OHTam BT474-AROM3 S phase MCF7-AROM1 S phase p=0.07 p=0.0035 p=0.005 p=0.002 p=0.037 p=0.039 p=0.0004 p=0.012 B BT474-AROM3 MCF7-AROM1 DCC-FBS RAD001 2nM And 10nM Let 100nM 4-OHTam 10nM DCC-FBS RAD001 2nM And 10nM Let 100nM 4-OHTam 10nM + - - - - + - - - - + + - - - + + - - - + - + - - + - + - - + + + - - + + + - - + - + + - + - + + - + + + + - + + + + - + - + - + + - + - + + + + - + + + + - + p-p27 ser10 p-p27 ser10 p27 p27 1.86 0.48 1.09 0.76 1.21 0.36 0.00 0.74 1.16 2.48 0.00 0.49 0.22 0.79 0.39 0.56 0.89 1.98 1.25 0.51 1.20 0.61 0.93 0.01 0.10 0.81 1.58 0.57 0.55 0.07 1.05 1.05 cyclin D3 cyclin D3 0.60 0.29 0.84 0.45 0.62 0.29 0.85 0.35 pRb 807 pRb 807 0.05 0.00 0.75 0.11 0.33 0.05 0.86 0.00 Rb Rb Actin Actin C MCF7-AROM1 AND +LET+RAD AND+4-OHT+RAD AND+ RAD AND +LET AND+4-OHT RAD AND DCC p27 To-pro-3 p=0.0003 p=1.5 x 10-5 p=0.003 DCC AND AND +LET AND+ 4-OHTam RAD AND+ RAD AND +LET+RAD AND+4-OHTam+RAD p=1.1 x 10-5 p=0.004 BT474-AROM3 AND +LET+RAD AND+4-OHT+RAD AND+ RAD AND +LET AND+4-OHT RAD AND DCC AND+ 4-OHTam+ RAD DCC AND AND +LET RAD AND+ RAD AND +LET+RAD AND+ 4-OHTam