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Genetic Map of Drosophila

Genetic Map of Drosophila. Fig. 5-14. P. M. Pairing of Homologous Chromosomes. Fig. 2-13, 2-14. Crossing Over Occurs Between DNA of Homologous Chromosomes. Paternal. Paired Homologous Chromosomes. Maternal. Fig. 2-8. Drosophila melanogaster (Fruit Fly). Phenotypes eye color

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Genetic Map of Drosophila

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  1. Genetic Map of Drosophila Fig. 5-14

  2. P M Pairing of Homologous Chromosomes Fig. 2-13, 2-14

  3. Crossing Over Occurs Between DNA of Homologous Chromosomes Paternal Paired Homologous Chromosomes Maternal

  4. Fig. 2-8

  5. Drosophila melanogaster (Fruit Fly) • Phenotypes • eye color • body color • wing shape • antenna length • bristle pattern

  6. Single Crossover (SCO) Paternal Paired Homologous Chromosomes Maternal

  7. Double Crossover (DCO) Paternal Paired Homologous Chromosomes Maternal DCO Products

  8. Pedigree for ABO Blood Group and Nail-Patella Syndrome

  9. HIV-1 Structure (Gp120)

  10. HIV Infection Pathway HIV-1 Extra-cellular Space Gp120 Membrane CCR5 Cytosol Protein encoded By CCR5-1 allele (CCR5-1 / CCR5-1 or CCR5-1 / CCR5-∆32)

  11. CCR5 RFLP CCR5-1 CCR5-∆32

  12. CCR5 Genotype Analysis Fig. 25-3

  13. CCR5-∆32 Allele Frequency Fig. 25-4

  14. Assumptions of the Hardy-Weinberg Equation Individuals of all genotypes have equal rates of survival and reproductive success (no selection). No new alleles are created or converted from one allele to another by mutation. Individuals do not migrate into or out of the population (no gene flow). The population is infinitely large (no genetic drift). Individuals in the population mate randomly (no inbreeding) Page 619-620

  15. Changes in CCR5-∆32 Allele Frequency Fig. 25-8

  16. Effect of Selection on Allele Frequency Fig. 25-7

  17. Pedigree Showing First Cousin Mating

  18. Organization of Human Genome (~ 50 kbp) Genes comprise ~ 5% of genome Repeated DNA comprises ~ 50% of genome (purple blocks) VNTR (Variable Number Tandem Repeat) STR (Short Tandem Repeat) Unique (“junk”) DNA comprises the rest Fig. 20-8 Pg. 494

  19. STR-A STR-B STR-C STR-D STR-E STR-F Chromosome 7

  20. 7M STR-A STR-B STR-C STR-D STR-E STR-F 7P GTCTAG GTCTAG GTCTAG CAGATC CAGATC CAGATC 7M GTCTAG GTCTAG GTCTAG GTCTAG CAGATC CAGATC CAGATC CAGATC 7P

  21. RFLP Analysis of VNTR Locus Fig. 22-27

  22. Fig. 22-28

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