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Neutropenia, Neupogen and Pain Management

Neutropenia, Neupogen and Pain Management. David C. Dale, MD. Neutropenia and Pain. Inflammation causes pain Mouth ulcers Gingivitis Abscesses and cellulitis Abdominal infections. G-CSF and Bone Pain. Common but variable side effect Mechanisms not understood No single best therapy

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Neutropenia, Neupogen and Pain Management

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  1. Neutropenia, Neupogen and Pain Management David C. Dale, MD

  2. Neutropenia and Pain Inflammation causes pain • Mouth ulcers • Gingivitis • Abscesses and cellulitis • Abdominal infections

  3. G-CSF and Bone Pain • Common but variable side effect • Mechanisms not understood • No single best therapy • Approach

  4. Approach • Expectations • Take smaller doses more often • Find smallest dose that works • Help us plan a study • “Use a ladder” Physical measures, NSAIDs, antihistamines, antidepressants, gabapentin, narcotic analgesics

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