RUNX1T1/RUNX1 Probe Fluorescence In Situ Hybridization in Placenta of a Stillborn Fetus

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This study examines the use of fluorescence in situ hybridization (FISH) with RUNX1T1/RUNX1 probes in a paraffin-embedded section of the placenta from a stillborn fetus with Down syndrome. The fetus presented with severe thrombocytopenic disorder (TMD) and acute megakaryoblastic leukemia (AMKL), linked to a GATA1 mutation. Findings highlight the genetic complexities associated with placental anomalies in affected cases, contributing to our understanding of prenatal development and associated conditions.

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Feb 12, 2026

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RUNX1T1/RUNX1 Probe Fluorescence In Situ Hybridization in Placenta of a Stillborn Fetus

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Figure 3 Fluorescence in situ hybridization with RUNX1T1/RUNX1 probes in a paraffin-embedded section of placenta Heald B et al. (2007) Severe TMD/AMKL with GATA1 mutation in a stillborn fetus with Down syndrome Nat Clin Pract Oncol 4: 433–438 doi:10.1038/ncponc0876