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This article discusses the pivotal roles of Toll-like receptors (TLRs), NOD-like receptors (NLRs), and the NLRP3 inflammasome in driving host defense and tissue repair. It emphasizes their involvement in the clearance of pathogens and cellular debris, as well as the regulation of repair pathways. The insights presented by Leemans et al. (2014) highlight the significance of pattern recognition receptors and inflammasomes in the context of kidney disease, offering valuable perspectives for understanding immune responses and tissue regeneration.
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Figure 3 TLRs, NLRs and the NLRP3 inflammasome drive host defence and tissue repair mechanisms by the clearance of pathogens and cell debris and by regulation of repair pathways Leemans, J. C. et al. (2014) Pattern recognition receptors and the inflammasome in kidney disease Nat. Rev. Nephrol. doi:10.1038/nrneph.2014.91