nrneph.2014.91-pf3

Sep 16, 2014

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Figure 3 TLRs, NLRs and the NLRP3 inflammasome drive host defence and tissue repair mechanisms by the clearance of pathogens and cell debris and by regulation of repair pathways. Leemans, J. C. et al. (2014) Pattern recognition receptors and the inflammasome in kidney disease

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tissue repair mechanisms
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nrneph.2014.91-pf3

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Figure 3 TLRs, NLRs and the NLRP3 inflammasome drive host defence and tissue repair mechanisms by the clearance of pathogens and cell debris and by regulation of repair pathways Leemans, J. C. et al. (2014) Pattern recognition receptors and the inflammasome in kidney disease Nat. Rev. Nephrol. doi:10.1038/nrneph.2014.91

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Figure 2 Features of subclinical or indolent ABMR, which is typically diagnosed in protocol biopsies performed at 3 months or 1 year after transplantation in kidney transplant recipients who have preformed DSAs and are receiving potent immunosuppressive conditioning.

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ncpneuro0261 pf3

Figure 3 Assembly of MHC class I peptide complexes in the ER of the muscle fiber for antigen presentation, and translocation of misfolded MHC class I heavy chain glycoproteins to the cytoplasm.

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nrneph.2013.22-pt1

Table 1 Studies in rats showing the involvement of vasopressin and V2Rs in CKDs, albuminuria and hypertension. Bankir, L. et al. (2013) Vasopressin: a novel target for the prevention and retardation of kidney disease? Nat. Rev. Nephrol. doi:10.1038/nrneph.2013.22.

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Sica, D. A. (2011) Diuretic use in renal disease Nat. Rev. Nephrol. doi:10.1038/nrneph.2011.175

Figure 3 The stages of CKD showing classification of CKD and diuretic use according to the NKF K/DOQI guidelines. Sica, D. A. (2011) Diuretic use in renal disease Nat. Rev. Nephrol. doi:10.1038/nrneph.2011.175.

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nrneph.2012.214-pf2

Figure 2 Recovery of renal function is better with a shorter interval between onset of aHUS and initiation of eculizumab. Zuber, J. et al. (2012) Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.214.

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nrneph.2013.110-pf1

Figure 1 Mechanisms by which aldosterone and/or MR activation induce oxidative stress, inflammation, and fibrosis. Brown, N. J. (2013) Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis Nat. Rev. Nephrol. doi:10.1038/nrneph.2013.110.

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ncprheum0424-pf3

Figure 3 Proposed analogy of the therapeutic mechanisms of IgG anti-RhoD and anti-CD20 monoclonal antibody treatment for immune thrombocytopenic purpura. Taylor RP and Lindorfer MA (2007) Drug Insight: the mechanism of action of rituximab in autoimmune

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nrneph.2012.196-pf3

Figure 3 Comparison of a mild case and severe case of STEC-HUS treated at the University Hospital in Hamburg–Eppendorf during the German outbreak in 2011. Trachtman, H. et al . (2012) Renal and neurological involvement in typical Shiga toxin-associated HUS

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nrneph.2009.67-pf1

Figure 1 Renal survival of patients in our study with pauci-immune crescentic glomerulonephritis with and without ANCAs. Permission obtained from the American Society of Nephrology  Chen, M. et al. Antineutrophil cytoplasmic autoantibody negative pauci-immune crescentic glomerulonephritis.

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nrcardio.2010.209-pf3

Figure 3 Odds ratio for waist index, waist-to-hip ratio, waist circumference, and BMI after adjustment for cardiovascular risk factors.

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ncpuro0657-pf3

Figure 3 Algorithm for the evaluation and treatment of postoperative voiding dysfunction and recurrent incontinence. Comiter CV (2006) Surgery Insight: management of failed sling surgery for female stress urinary incontinence Nat Clin Pract Urol 3: 666 – 674 doi:10.1038/ ncpuro0657.

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nrurol.2011.236-pf3

Figure 3 Deletions and mutations of VHL , PBRM1 , BAP1 and SETD2 genes on chromosomal locus 3p.

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nrneph.2012.214-pt1

Table 1 Evidence supporting the role of complement dysregulation and the benefit of C5 blockade in aHUS and C3G. Zuber, J. et al. (2012) Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.214.

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nrneph.2012.214-pt2

Table 2 Clinical and genetic characteristics of 24 off-trial patients treated with eculizumab for overt aHUS. Zuber, J. et al. (2012) Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.214.

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ncpgasthep0717-pf3

Figure 3 A two-step model for the involvement of genetic factors in the pathophysiology of functional gastrointestinal disorders. Adam B et al . (2007) Mechanisms of Disease: genetics of functional gastrointestinal disorders—searching

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ncponc0688 pf3

Figure 3 Disease distribution in publications detailing bisphosphonate-related ONJ (derived from data in Table 2).

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nrgastro.2013.178 pf3

Figure 3 Open questions regarding the role of the colonic microbiome in the development of adenomas and in the different stages of CRC. Konstantinov, S. R. et al. (2013) Functional genomic analyses of the gut microbiota for CRC screening

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nrgastro.2013.216 pf3

Figure 3 A management algorithm for patients with HBV infection prior to starting immunosuppressive therapy. Hwang, J. P. & Lok, A. S.-F. (2013) Management of patients with hepatitis B who require immunosuppressive therapy Nat. Rev. Gastroenterol. Hepatol. doi:10.1038/nrgastro.2013.216.

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nrneph.2012.249 pf2

Figure 2 The aldosterone paradox. Aldosterone exerts differential effects during hypovolaemia and hyperkalaemia. Sevá Pessôa, B. et al . (2012) Key developments in renin–angiotensin–aldosterone system inhibition Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.249.

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nrneurol.2013.276 pf3

Figure 3 Multivariate pattern classification can discriminate between multiple subgroups of ASD on the basis of neuroimaging data. Ecker, C. & Murphy, D. (2014) Neuroimaging in autism—from basic science to translational research Nat. Rev. Neurol. doi:10.1038/nrneurol.2013.276.

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nrneph.2012.213 pf2

Figure 2 Activation of C3 convertase is involved in both complement-mediated and immune-complex-mediated MPGN. Bomback, A. S. & Appel, G. B. (2012) Pathogenesis of the C3 glomerulopathies and reclassification of MPGN Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.213.

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ncponc0876 pf3

Figure 3 Fluorescence in situ hybridization with RUNX1T1/RUNX1 probes in a paraffin-embedded section of placenta. Heald B et al. (2007) Severe TMD/AMKL with GATA1 mutation in a stillborn fetus with Down syndrome Nat Clin Pract Oncol 4 : 433 –438 doi:10.1038/ncponc0876.

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