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MAIN-COMPARE Study

MAIN-COMPARE Study. Stents versus Coronary-Artery Bypass Grafting for Left Main Coronary Artery Disease. MAIN-COMPARE Study. MAIN-COMPARE Study. Presented at ACC / i2 2008 in Chicago Presented by Dr. Seung-Jung Park. Copyleft Clinical Trial Results. You Must Redistribute Slides.

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MAIN-COMPARE Study

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  1. MAIN-COMPARE Study Stents versus Coronary-Artery Bypass Grafting for Left Main Coronary Artery Disease

  2. MAIN-COMPARE Study MAIN-COMPARE Study Presented at ACC / i2 2008 in Chicago Presented by Dr. Seung-Jung Park Copyleft Clinical Trial Results. You Must Redistribute Slides

  3. MAIN-COMPARE Study: Background • Coronary artery bypass graft (CABG) surgery has been regarded as the standard of care in LMCA disease. • Early trials of LMCA disease treatment with drug eluting stents (DES) suggest promising outcomes with respect to mortality. Presented at SCAI-i2 summit 08

  4. MAIN-COMPARE Study: Study Design 2240 patients with unprotected left main artery disease, excluding those with prior CABG, valvular & aortic surgery, STEMI, or cardiogenic shock Prospective. Non-randomized. Observational. 49% underwent stent implantation and 51% underwent CABG surgery R Stent implantation n=1102 CABG surgery n=1138 R DES n=784 BMS n=318 1017 days median follow-up 1152 days median follow-up • Primary Endpoint: Death; the composite of death, Q-wave myocardial infarction or stroke; target vessel revascularization (TVR). Presented at SCAI-i2 summit 08

  5. MAIN-COMPARE Study: Baseline Characteristics Copyleft Clinical Trial Results. You Must Redistribute Slides Presented at SCAI-i2 summit 08

  6. MAIN-COMPARE Study: Angiographic Characteristics Copyleft Clinical Trial Results. You Must Redistribute Slides Presented at SCAI-i2 summit 08

  7. MAIN-COMPARE Study: EndpointsOverall cohort HR is risk of stenting in excess of CABG Copyleft Clinical Trial Results. You Must Redistribute Slides Presented at SCAI-i2 summit 08

  8. MAIN-COMPARE Study: EndpointsBMS vs. CABG HR is risk of stenting in excess of CABG Copyleft Clinical Trial Results. You Must Redistribute Slides Presented at SCAI-i2 summit 08

  9. MAIN-COMPARE Study: EndpointsDES vs. CABG Copyleft Clinical Trial Results. You Must Redistribute Slides Presented at SCAI-i2 summit 08

  10. MAIN-COMPARE Study: Limitations • This was a non-randomized, observational study, thus the results may have been influenced by confounders. • Additionally, a larger sample size is needed to appropriately power the study in order to detect significant differences in mortality. Presented at SCAI-i2 summit 08

  11. MAIN-COMPARE Study: Summary • The results of this study suggest that there is no significant difference in the mortality rate or the composite risk of death, Q-wave MI or stroke among patients with unprotected LMCA disease who undergo PCI vs. CABG. • However, CABG was associated with significant reduction in the incidence of target vessel revascularization compared to PCI. Presented at SCAI-i2 summit 08

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