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National Reference Center for AIDS –UBA Hospital Fernandez, Infectious Diseases Unit

RT mutations patterns associated with cross-resistance to NRTI or NNRTI in samples of experienced HIV patients from Buenos Aires. National Reference Center for AIDS –UBA Hospital Fernandez, Infectious Diseases Unit Buenos Aires, Argentina

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National Reference Center for AIDS –UBA Hospital Fernandez, Infectious Diseases Unit

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  1. RT mutations patterns associated with cross-resistance to NRTI or NNRTI in samples of experienced HIV patients from Buenos Aires National Reference Center for AIDS –UBA Hospital Fernandez, Infectious Diseases Unit Buenos Aires, Argentina *SUPPORTED BY THE FOGATY INTERNATIONAL CENTER MI Figueroa*, O. Sued, N. Laufer*, F. Moretti, S. Pampuro, M. Gomez Carrillo, H. Salomon, P. Cahn TUPDA204

  2. OBJECTIVE • To describe the prevalence of RT mutations associated with cross resistance to NRTI and NNRTI ARVs in HIV experienced patientsin one Resistance Database in Buenos Aires. • METHODS • 2959 samplesofHIV experienced patients • 2001 and 2007 • National Reference Center for AIDS –UBA • IAS-USA2007 Drug Resistance Mutations • DEFINITIONS RT mutations patterns associated with cross-resistance to NRTI/NNRTI. • MultiNRTI resistance mutations : K65R, 69ins, Q151M or 6 TAMs • (41L, 67N, 70R, 210W, 215Y/F, 219Q/E) • MultiNNRTIresistance mutations: K103N

  3. RESULTS

  4. CONCLUSIONS • MultiNRTI resistance is prevalent in our database • 8% of analyzed samples have no NRTI options • K65R mutation has increased, probably due to introduction of TDF (in 2003) • One third of samples are resistant to first-generation NNRTIs • Second-generation NNRTIs (ETR) could be a treatment option

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