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Enrolled 95

Enrolled 95. Expansion cohorts*. Dose escalation cohorts. Allocated to BID schedule(n=26) Received OSI-906 (n=24 ). Allocated to BID schedule(n=31) Received OSI-906 (n=29 ). Allocated to QD schedule (n=38) Received OSI-906 (n=33).

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Enrolled 95

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  1. Enrolled 95 Expansion cohorts* Dose escalation cohorts Allocated to BID schedule(n=26) Received OSI-906 (n=24) Allocated to BID schedule(n=31) Received OSI-906 (n=29) Allocated to QD schedule (n=38) Received OSI-906 (n=33) Discontinued (n=33) Disease progression (n=21) Adverse event (n=7) Medical/ ethical reasons (n=1) Patient request (n=4) Discontinued (n=23) Disease progression (n=17) Adverse event (n=4) Medical/ ethical reasons (n=1) Patient request (n=1) Discontinued (n=28) Disease progression (n=26) Adverse event (n=2) Evaluated for: Safety (n=33) DL T (n=27) Pharmacokinetics (n=33) Efficacy (n=24) Evaluated for: Safety (n=22) DL T (n=22) Pharmacokinetics (n=24) Efficacy (n=19) Evaluated for: Safety (n=29) Pharmacokinetics (n=29) Efficacy (n=22) Figure 1. Patient disposition. *Including nine patients in the diabetes expansion cohort and twenty patients in the biomarker expansion cohort

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