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Understanding the Simplified TCA Cycle: From Pyruvate to Energy Production

The TCA cycle, also known as the Krebs cycle, is a crucial metabolic pathway that converts pyruvate into energy. It begins with the 3-carbon pyruvate, derived from glycolysis, and involves multiple steps producing CO2, NADH, and FADH2. The cycle operates in three phases, starting with the transformation of pyruvate to a 6-carbon compound, followed by various reactions that yield energy carriers like NADH, FADH2, and GTP, while releasing CO2. Understanding this cycle is essential for grasping cellular respiration and energy metabolism.

andrew-ortega
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Understanding the Simplified TCA Cycle: From Pyruvate to Energy Production

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  1. A simplified TCA cycle Pyruvate (3C; from glycolysis) NAD+ CO2 + NADH + H+ 2C 6C NADH + H+ 4C 6C 4C Phase 1 6C Phase 3 NAD+ 4C Phase 2 CO2 + NADH + H+ 5C FADH2 NAD+ 4C 4C CO2 + NADH + H+ GTP

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