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Exploring Orthologs, Diseases, and Interactions: Integrating Gene Data and Ontologies

This presentation highlights the integration of orthologs, diseases, and gene interactions, showcasing tools to search for "cardio" related genes and diseases. It discusses the various reports available, including orthology and disease summaries, and highlights the upgrades in ontology browser functionalities. The collaboration with OMIM, Reactome, and HapMap projects to enhance data accessibility is emphasized. Acknowledgments are made to the team members and contributors involved in advancing the project. Dive into the interconnections between genes, diseases, and their respective ontologies.

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Exploring Orthologs, Diseases, and Interactions: Integrating Gene Data and Ontologies

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Presentation Transcript

  1. Orthologs, Diseases, and Interactions Norie de la Cruz

  2. Moving through and across the data Interaction Orthologs Gene Disease Ontology

  3. Disease Search for “cardio”

  4. Genes and Diseases

  5. To and from genes Gene to interactions ….

  6. Interactions Summary for gene

  7. Interaction Report

  8. To and from genes Gene to Other orthologs and diseases ….

  9. List of orthologs for gene

  10. Orthology Report

  11. List of diseases for gene

  12. Searching Multiple Ontologies

  13. Multiple ontology search results

  14. Ontology browser upgrade

  15. The fun goes on …. • Work with OMIM to link back to WB • Addition of OMIM data to AceDB • Links to and from Reactome and HapMap projects

  16. Thank you!

  17. End Succeeding slides are extra !!!

  18. Reports • Back and forth links between ontologies and associated objects • Back and forth links to related terms in other ontologies • Browser with links to WormMart

  19. Orthology and Disease • Search functionalities • Interlinking between pages

  20. Disease Report

  21. Disease Search

  22. Acknowledgements • Todd Harris • Lincoln Stein • Dev Group: Sheldon Mckay, Will Spooner, Zheng Zha • WormBase staff

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