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Impact of JPIAMR-Funded Projects: Strategy Development & Project Overview

This document provides an overview of JPIAMR-funded projects and networks in transmission, environment, and therapeutics research, highlighting the strategies and impacts of these projects. It also includes showcases of specific projects and their relevance to antimicrobial resistance. Explore the distribution of projects based on pathogens investigated, learn about the priority pathogens addressed, and discover the various research approaches and interventions being pursued. Additionally, find publication metrics and contact information for further inquiries.

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Impact of JPIAMR-Funded Projects: Strategy Development & Project Overview

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  1. Impact of JPIAMR funded projects: Strategy development Shawon Lahiri MB meeting 23-24 October, 2018 Leuven

  2. Both quantity and quality Publications, Products and Interventions

  3. Overview of JPIAMR funded projects and networks

  4. Overview of the Joint Transnational Calls Supported by JPIAMR

  5. JPIAMR Transnational projects

  6. JPIAMR Transnational projects

  7. JPIAMR Transnational Networks

  8. Overview of JPIAMR funded projects in Transmission

  9. JPIAMR funded 19 projects in Transmission research Distribution of JPIAMR funded projects on the basis of pathogens investigated JPIAMR supported research projects addressing pathogens categorized under WHO Priority Pathogens List WHO priority pathogens Critical (Priority 1) High (Priority 2) Medium (Priority 3) Others

  10. Showcase: JPIAMR supported network related to Transmission and Environment Flies (Diptera: Muscidae) and the spread of antimicrobial resistant bacteria – JPIAMR supported network Travel Medicine and Infectious Disease 22 (2018) 8–17 Modes of bacterial transmission between humans and animals through ‘filth flies’.

  11. Overview of JPIAMR funded projects and networks in Environment Keywords from JPIAMR supported projects in Environment

  12. Showcase: JPIAMR supported projects related to Environment and Water Antibiotic Resistance in Wastewater: Transmission Risks for Employees and Residents around Waste Water Treatment Plants (AWARE-WWTP) Gene-gas: Wastewater treatment plants as critical reservoirs for resistance genes To assess carriage of extended-spectrum betalactamase (ESBL) and carbapenemase-producing Enterobacteriaceae and resistance genes in WWTP workers, in residents in the proximity of treatment plants, and in water and air samples – both in countries with low and high antimicrobial resistance (AMR). • Schematic representation of the proposed project. • Resistance genes from both bacteria and bacteriophages will be monitored in wastewater treatment plants • Novel means will be developed to reduce the “survival” of the genes in WWTP, reducing the spread of resistance genes through • transformation and transduction. • Finally, a mathematical model to predict spreading of resistance genes in WWTP, and the impact of novel treatments, will be developed.

  13. Overview of JPIAMR funded projects in Therapeutics

  14. JPIAMR funded 20 projects in Therapeutics research Distribution of JPIAMR funded projects on the basis of pathogens studied JPIAMR supported research projects addressing pathogens categorized under WHO Priority Pathogens List WHO priority pathogens Critical (Priority 1) TB High (Priority 2) Medium (Priority 3) Others Majority of the projects involve Critical (Priority 1) pathogens A fair distribution of projects investigating other priority pathogens as well

  15. JPIAMR invest in new drugs and alternative approaches Classification of the projects on the basis of their aims Plant extracts CRISPER/Cas (phage therapy) Ribosome-targeting antibiotics Mycobacterial Tolerance Inhibitors Nanoparticles Virulence secretion system Inhibitors Biofilm-targeting phage therapy Optimizing the structure of previously identifiedMBL inhibitors Peptide Nucleic Acids Inhibitors for Metallo-Beta-Lactamase (MBL) Alternative approaches Novel candidate/ strategies Efflux pumps blockers Combination of Neglected and Disused Antibiotics (ND-AB) Biofilm-disrupting agents Secondary metabolites Drugable sites in trans-peptidases Combination of ND-AB with immuno- stimulatory drugs Flavodoxin inhibitor antibiotics Siderophore conjugated antibiotics Antibiotics targeting persisters Thiamine pyro-phosphate riboswitch inhibitors WHO priority pathogens Critical (Priority 1) Critical/ Mycobacterium tuberculosis High (Priority 2) Medium (Priority 3) All pathogens

  16. Strategic approach – trial

  17. Strategic approach – trial

  18. Publication metrics Citations per publication Number of publications JPIAMR has been mentioned Publications for different research categories

  19. Publication metrics

  20. Thankyou! www.jpiamr.eu @JPIonAMR secretariat.jpiamr@vr.se

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