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Metalloproteins and Metalloenzymes

Metalloproteins and Metalloenzymes

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Metalloproteins and Metalloenzymes

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  1. Metalloproteins and Metalloenzymes 3.1 Uptake吸收, Storage储存 and Transport运输 3.2 Biological Chemistry of Iron, copper, and Zinc 3.3 Biological Chemistry of Other Metals

  2. Distribution of Iron, Zinc, and Copper • Fe out of a total of 4-5 g: 60-70% hemoglobin; 7-15% ferritin铁蛋白; 3-5% myoglobin肌红蛋白; 0.1% catalase过氧化氢酶; 0.1% cytochromes细胞色素类 • Zn out of a total of 1.4-2.3 g: liver肝 55 mg; kidney肾 55 mg; muscle肌肉 54 mg; heart 33 mg; pancreas胰 29 mg; spleen脾 21 mg; lung肺 15 mg; brain 14 mg; adrenal肾上腺12 mg; prostate前列腺 102 mg. • Cu out of a total of 80-120 mg: 8 mg in liver; 15 mg in heart, spleen, kidneys, brain, blood; concentrated in the pigment parts of eyes

  3. Protein Carriers in Blood Plasma Carrier Ion Transferrin转铁蛋白 Fe3+ Ceruloplasmin血浆铜蓝蛋白 Cu2+ Albumin清蛋白 Zn2+, Cu2+ Metallothionein金属硫蛋白 Zn2+, Cu2+, Cd2+, Hg2+, Co2+, Pb2+, Ag+ Phosphoproteins Ca2+ Non required Mg2+, Na+ ,K+

  4. Ion Storage Proteins Ion Ferritin铁蛋白 Fe3+ Metallothineine Cu2+, Zn2+, Heavy Metals Ceruloplasmin Cu2+, Zn2+ Serum Albumin Cu2+, Zn2+ Phosphoproteins Ca2+

  5. Metalloproteins and Metalloenzymes • conjugated proteins = protein + prosthetic (cofactor) • Holo-enzyme = apo-enzyme + prosthetic (cofactor)

  6. Classification of Metalloproteins Dioxygen Carriers氧载体 Redox Protein氧化还原蛋白 • Classification of Metalloenzymes Oxido-reductase 氧化还原酶 Transferase转移酶 Hydrolase水解酶 Lyase裂解酶 Isomerase异构酶 Ligase连接酶

  7. Bioinorganic Chemistry of Iron • Oxygen Carriers: hemoglobin血红蛋白, myoglobin肌红蛋白, hemerythrin蚯蚓血红蛋白 • Redox proteins: iron sulfur protein铁流蛋白, cytochrome c细胞色素c, cytochrome b5细胞色素b5, etc. • Redox enzymes: cytochrome p450细胞色素p450, peroxidase过氧化物酶, catalase过氧化氢酶,etc.

  8. Bioinorganic Chemistry of Zinc • Hydrolysis Enzymes - Lewis Acid carbonic anhydrase碳酸酐酶 carboxypeptidase羧肽酶 alkaline phosphatase碱性磷酸酯酶 proteinase • NAD-dependent dehydrogenases alcohol dehydrogenase醇脱氢酶 glutamate dehydrogenase谷氨酸脱氢酶 lactate dehydrogenase乳酸脱氢酶 malate dehydrogenase苹果酸脱氢酶 * Structure Roles

  9. Bioinorganic Chemistry of Copper • Oxygen Carriers Hemocyanin血蓝蛋白 • Redox Proteins-Electron Transfer Protein Plastocyanin质体蓝素 Azurin天青素 Stellacyanin • Oxido-Reductase

  10. Oxido-Reductase Enzymes Superoxide Dismutase超氧化物岐化酶 Tyrosinase酪氨酸酶 Laccase漆酶 Ascorbate Oxidase抗坏血酸氧化酶 Galactose Oxidase半乳糖氧化酶 Dopamine-B-Hydroxylase多巴胺羟化梅 Amine Oxidase胺氧化酶 Urate Oxidase尿酸氧化酶 Cytochrome c Oxidase细胞色素c氧化酶 Hi, how are you!