1 / 10

Metalloproteins and Metalloenzymes

Metalloproteins and Metalloenzymes. 3.1 Uptake 吸收 , Storage 储存 and Transport 运输 3.2 Biological Chemistry of Iron, copper, and Zinc 3.3 Biological Chemistry of Other Metals. Distribution of Iron, Zinc, and Copper.

aolani
Télécharger la présentation

Metalloproteins and Metalloenzymes

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Metalloproteins and Metalloenzymes 3.1 Uptake吸收, Storage储存 and Transport运输 3.2 Biological Chemistry of Iron, copper, and Zinc 3.3 Biological Chemistry of Other Metals

  2. Distribution of Iron, Zinc, and Copper • Fe out of a total of 4-5 g: 60-70% hemoglobin; 7-15% ferritin铁蛋白; 3-5% myoglobin肌红蛋白; 0.1% catalase过氧化氢酶; 0.1% cytochromes细胞色素类 • Zn out of a total of 1.4-2.3 g: liver肝 55 mg; kidney肾 55 mg; muscle肌肉 54 mg; heart 33 mg; pancreas胰 29 mg; spleen脾 21 mg; lung肺 15 mg; brain 14 mg; adrenal肾上腺12 mg; prostate前列腺 102 mg. • Cu out of a total of 80-120 mg: 8 mg in liver; 15 mg in heart, spleen, kidneys, brain, blood; concentrated in the pigment parts of eyes

  3. Protein Carriers in Blood Plasma Carrier Ion Transferrin转铁蛋白 Fe3+ Ceruloplasmin血浆铜蓝蛋白 Cu2+ Albumin清蛋白 Zn2+, Cu2+ Metallothionein金属硫蛋白 Zn2+, Cu2+, Cd2+, Hg2+, Co2+, Pb2+, Ag+ Phosphoproteins Ca2+ Non required Mg2+, Na+ ,K+

  4. Ion Storage Proteins Ion Ferritin铁蛋白 Fe3+ Metallothineine Cu2+, Zn2+, Heavy Metals Ceruloplasmin Cu2+, Zn2+ Serum Albumin Cu2+, Zn2+ Phosphoproteins Ca2+

  5. Metalloproteins and Metalloenzymes • conjugated proteins = protein + prosthetic (cofactor) • Holo-enzyme = apo-enzyme + prosthetic (cofactor)

  6. Classification of Metalloproteins Dioxygen Carriers氧载体 Redox Protein氧化还原蛋白 • Classification of Metalloenzymes Oxido-reductase 氧化还原酶 Transferase转移酶 Hydrolase水解酶 Lyase裂解酶 Isomerase异构酶 Ligase连接酶

  7. Bioinorganic Chemistry of Iron • Oxygen Carriers: hemoglobin血红蛋白, myoglobin肌红蛋白, hemerythrin蚯蚓血红蛋白 • Redox proteins: iron sulfur protein铁流蛋白, cytochrome c细胞色素c, cytochrome b5细胞色素b5, etc. • Redox enzymes: cytochrome p450细胞色素p450, peroxidase过氧化物酶, catalase过氧化氢酶,etc.

  8. Bioinorganic Chemistry of Zinc • Hydrolysis Enzymes - Lewis Acid carbonic anhydrase碳酸酐酶 carboxypeptidase羧肽酶 alkaline phosphatase碱性磷酸酯酶 proteinase • NAD-dependent dehydrogenases alcohol dehydrogenase醇脱氢酶 glutamate dehydrogenase谷氨酸脱氢酶 lactate dehydrogenase乳酸脱氢酶 malate dehydrogenase苹果酸脱氢酶 * Structure Roles

  9. Bioinorganic Chemistry of Copper • Oxygen Carriers Hemocyanin血蓝蛋白 • Redox Proteins-Electron Transfer Protein Plastocyanin质体蓝素 Azurin天青素 Stellacyanin • Oxido-Reductase

  10. Oxido-Reductase Enzymes Superoxide Dismutase超氧化物岐化酶 Tyrosinase酪氨酸酶 Laccase漆酶 Ascorbate Oxidase抗坏血酸氧化酶 Galactose Oxidase半乳糖氧化酶 Dopamine-B-Hydroxylase多巴胺羟化梅 Amine Oxidase胺氧化酶 Urate Oxidase尿酸氧化酶 Cytochrome c Oxidase细胞色素c氧化酶 Hi, how are you!

More Related