The von Hippel-Lindau (VHL) Tumor Suppressor Gene and Its Role in Hypoxia-Dependent Gene Regulation

Dec 16, 2025

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This presentation explores the von Hippel-Lindau (VHL) tumor suppressor gene, focusing on its critical function in regulating hypoxia-dependent gene transcription. The VHL gene plays a pivotal role in oxygen homeostasis and tumorigenesis, as its dysfunction is associated with various cancers. We will discuss the mechanisms through which VHL influences the expression of genes involved in response to low oxygen levels, shedding light on therapeutic avenues and potential implications for cancer treatment.

1 von hippellindau2 tumor suppressor gene3 hypoxiadependent genes4 gene regulation5 cancer biology6 oxygen homeostasis7 transcription factors8 tumorigenesistext

april-harmon

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The von Hippel-Lindau (VHL) Tumor Suppressor Gene and Its Role in Hypoxia-Dependent Gene Regulation

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