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Male and Female Hormones

Objectives. Identify the sources of male and female hormones.Describe the pharmacokinetics of male and female hormones.Describe the mechanism of action of male and female hormones.Explain the clinical uses of male and female hormones. The Gonadal Hormones. Sex hormones are produced by the gonads.

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Male and Female Hormones

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    1. Male and Female Hormones Dr. Rajaa A. Mirghani

    2. Objectives Identify the sources of male and female hormones. Describe the pharmacokinetics of male and female hormones. Describe the mechanism of action of male and female hormones. Explain the clinical uses of male and female hormones

    3. The Gonadal Hormones Sex hormones are produced by the gonads. Important for conception, embryonic maturation, and development of primary and secondary sexual characteristics at puberty. Synthesized from the precursor, cholesterol Female (estrogens & progestins) & Male (androgens)

    4. Therapeutic Uses Hormonal replacement therapy Contraception Management of menopausal symptoms Cancer chemotherapy (antagonists)

    5. Female Sex Hormones The principle and most potent estrogen in the premenopausal woman is Estradiol (17 ß-estradiol) is produced and secreted by the ovary. Estrone is a metabolite of estradiol and is the primary circulating estrogen after menopause (generated mainly from conversion of androstenedione in peripheral tissues). Estriol is another metabolite of estradiol, is significantly less potent than estradiol. It is present in significant amounts during pregnancy, because it is the principal estrogen produced by the placenta.

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