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This study investigates the changes in podocyte morphology in diabetic models over a 6-week period. We analyze glomerular sections to assess variations in GV/P (glomerular volume per podocyte) in both control and diabetic groups, including those treated with insulin. Our results aim to elucidate the impact of diabetes and insulin therapy on podocyte health and glomerular structure, providing insights into diabetic nephropathy progression. Significant findings include comparative metrics between treatment groups and control.
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WT-1 6 weeks ** 20 ** 3000 15 2000 Podocytes/glomerular section 10 GV/P (mm3) 1000 5 0 0 Control Diabetic Diab.+ins. Control Diabetic Diab.+ins. GLEPP1 6 weeks 20 * ** * 15 4000 3000 10 Podocytes/glomerular section 2000 GV/P (mm3) 5 1000 0 0 Control Diabetic Diab.+ins. Control Diabetic Diab.+ins.