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Protein Structure 2

This guide explores the hierarchy of protein structure, detailing the primary, secondary, tertiary, and quaternary levels. Learn about the significance of amino acid sequences, recurring structural motifs, and supersecondary structures like alpha-fibrous proteins and beta sheets. Discover how domains serve distinct functions within tertiary structures, alongside examples of structural motifs such as DNA binding and kinase phosphorylation. This comprehensive overview provides essential insights into protein folding and its implications in molecular biology.

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Protein Structure 2

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  1. Protein Structure 2 Higher Order Protein Structures

  2. Hierarchy of Protein Structure Primary sequence- The amino acid sequence of a polypeptide, listed from N-terminus to C-terminus. Secondary structure- Recurring structural feature of proteins stabilized exclusively by hydrogen bonds between peptide bond elements. Supersecondary structure- Recurring structural feature of proteins composed of two or more secondary structural elements. Domain- A segment of protein structure that is autonomously stable. Tertiary structure- A stable, independent protein encoded by a single gene. Quaternary structure- A complex structure composed of two or more tertiary structure subunits.

  3. Alpha-fibrous proteins: Coiled-coil Helix Supersecondary Structure Heptad repeats in GCN4 Four-helical bundle

  4. Sequence Comparison Reveals Positional Preference Within Heptad Repeats

  5. Max1 as an Example of a Leucine Zipper Motif Protein

  6. Parallel and Anti-parallel Beta Sheets anti-parallel parallel

  7.  Supersecondary Structures Structure of -grasp fold of ubiquitin showing  motif Repeating  motifs (n=7) form a Rossmann fold structure

  8.  Supersecondary Structures Greek key motif Beta meander motif

  9. -coil- Supersecondary Structure IpaH3.0

  10. Domains and Tertiary Structure Domains- Structurally autologous structures possessing discrete functions that comprises part of the tertiary structure (beads on a string). Domains can be identified by their characteristic sequences. Ex: DNA binding domains, NAD+/NADP+ binding domains, HECT domains, Zn finger domains, etc. Motif- A highly conserved, short amino acid sequence that identifies a discrete function. Ex: Protein kinase phosphorylation motifs, Ca++ binding motifs, etc. Pyruvate kinase domain structure

  11. Quaternary Structure

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