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How Does HIV-I Positive and Negative Antibody Status Patients Compare With the CKR5 Genotype?

How Does HIV-I Positive and Negative Antibody Status Patients Compare With the CKR5 Genotype?. The Different Risk Groups. Exposed homosexual men, who had positive and negative antibody status. Exposed hemophiliacs, who had positive and negative antibody status men. Types of CKR5 Genotypes.

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How Does HIV-I Positive and Negative Antibody Status Patients Compare With the CKR5 Genotype?

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  1. How Does HIV-I Positive and Negative Antibody Status Patients Compare With the CKR5 Genotype?

  2. The Different Risk Groups • Exposed homosexual men, who had positive and negative antibody status. • Exposed hemophiliacs, who had positive and negative antibody status men.

  3. Types of CKR5 Genotypes • Homozygous wild type (+/+) • Heterozygous (+/∆32) • Homozygous mutant type (∆32/∆32)

  4. Data for Homosexual Men and Hemophiliacs

  5. Summary on homosexual’s and data • Most of the studies had more positive than negative antibody status except for one study done for homosexuals. • Only the negative subjects seemed to have the homogenous mutant CKR5 • The positive subjects showed no presence of the mutant CKR5.

  6. Summary on Hemophiliac’s data • Hemophiliac positive patients show no presence of the homo-mutant CKR5, but all others were present. • Hemophiliac negative patients showed presence of homo-mutant CKR5 in one study, and no presence in another study (different cohort study). • Hemophiliac negative patients had other CKR5 genotypes present.

  7. What Can Be Concluded? • The patients with the most diverse genotypes were the HIV-I negative patients • The HIV-I positive patients showed only the homozygous wild-type and heterozygous genotypes. • HIV-I negative patients may have a longer nonprogressive rate due to their diversity in genotype.

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