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Antibody Structure

Antibody Structure. B cell activation. Antibody-Mediated E ffector Functions. Antibody Classes.  Immunoglobulin G ( IgG )  Most abundant class  Four subclasses  Activate complement system. Antibody Classes.  Immunoglobulin M ( IgM )  Pentamer  1 st class produced in response

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Antibody Structure

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  1. Antibody Structure

  2. B cell activation

  3. Antibody-Mediated Effector Functions

  4. Antibody Classes Immunoglobulin G (IgG) Most abundant class Four subclasses Activate complement system

  5. Antibody Classes Immunoglobulin M (IgM) Pentamer 1st class produced in response to an antigen Activates complement system

  6. Antibody Classes Immunoglobulin A (IgA) Predominant class in secretions Secretory IgA

  7. Antibody Classes Immunoglobulin E (IgE) Hypersensitivity reactions

  8. Antibody Classes Immunoglobulin D (IgD) Major membrane-bound immunoglobulin expressed by mature B cells.

  9. Antigenic determinants on immunoglobulins Isotype Allotype Idiotype

  10. Humoral and Cellular Immunity •Humoral immunity – Host defenses that are mediated by antibody present in the plasma, lymph and tissue fluids. •Cellular immunity – Host defenses that are mediated by antigen-specific T cells and various nonspecific cells of the immune system.

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