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Modified SIR for Vector-Borne Diseases

Modified SIR for Vector-Borne Diseases. Gay Wei En Colin 4i310 Chua Zhi Ming 4i307 Jacob Savos AOS Katherine Kamis AOS. Content Page. Introduction Aims and Objectives Rationale Literature Review Research Questions Data Collection – Population Data Analysis – Population.

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Modified SIR for Vector-Borne Diseases

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  1. Modified SIR for Vector-Borne Diseases Gay Wei En Colin 4i310 Chua Zhi Ming 4i307 Jacob SavosAOS Katherine KamisAOS

  2. Content Page • Introduction • Aims and Objectives • Rationale • Literature Review • Research Questions • Data Collection – Population • Data Analysis – Population • Methodology • Timeline • Assumptions • Obstacles Faced • Model • Data Collection – Climate • Data Analysis – Climate • Bibliography

  3. Introduction • A vector-borne disease is transmitted by a pathogenic microorganism from an infected host to another organism • HCI will be creating a model using Dengue Fever • AOS will be creating a model using a tick-borne disease

  4. Aims and Objectives • To create a universal modified SIR model for vector-borne diseases to make predictions of the spread of diseases.

  5. Rationale • The SIR Model currently used is extremely simplistic • Only considers three compartments, namely Susceptible, Infected and Recovered • Two directions of change, namely from Susceptible to Infected or from Infected to Recovered

  6. Rationale • Since most vector-borne diseases do not work in such a way, this project aims to modify this SIR model so that it can encompass much more factors that the original SIR model • Birth and death rates • Movement from Recovered to Susceptible • Make it more applicable to real life, thus increasing its usability in accurately predicting the spread of such vector-borne diseases.

  7. Literature Review:SIR Model • Neuwirth, E., & Arganbright, D. (2004). The active modeler: mathematical modeling with Microsoft Excel. Belmont, CA: Thomson/Brooks/Cole. • Introduces basic modeling techniques such as dynamic modeling and graphing • Rates of change are shown to have relations between the three compartments: S(t), I(t) and R(t) in the subtopic simple epidemics. • Calculus can be used to help us solve the research questions mentioned.

  8. Literature Review:Dengue Fever • A very old disease that reemerged in the past 20 years • Transmitted via mosquito bites • In 2009, there were a total of 4452 cases of dengue fever in Singapore, of which there were 8 deaths

  9. Literature Review:Aedes Mosquitoes • Aedes mosquitoes refers to the entire genus of mosquito – over 700 different species • Multiple species able to transmit dengue fever • Have characteristic black and white stripe markings on body and legs Aedesalbopictus – the most invasive mosquito in the world Retrieved from http://www.comune.torino.it/ucstampa/2005/aedes-albopictus.jpg Aedesaegypti – Main vector of dengue fever in Singapore Retrieved from http://www.telepinar.icrt.cu/ving/images/stories/aedes-aegypti__785698.jpg

  10. Methodology • Begin with a simple SIR model • Develop variables needed to modify the model • Attempt to modify the model to incorporate all vector-borne diseases Birth Death Death Net Migration Hosts Susceptible Infected Vectors Infected Susceptible Climate Climate

  11. Differentiation • Used to determine the rate of change of a function • Infection and recovery obtained via differentiation based on data acquired • e.g. With the weekly number of cases of the disease, we are able to find the best fit graph, the function of which we can then differentiate to determine the infection rate in the form of a function.

  12. Timeline

  13. Data Collection – Number of Weekly Cases • Extracted from: • Weekly Infectious Disease Bulletin • Published by the Ministry of Health, Singapore.

  14. Data Analysis – Number of Weekly Cases • Calculation of Transmittal Constant (k) and Contact Probability (CP)

  15. Data Collection - Population • We collected annual data for: • Population • Birth • Death • Net Migration

  16. Data Analysis - Population • The population of the subsequent years were predicted based on the data extracted. • The change in population were predicted based on the annual births, deaths and net migration. • The data collected were plotted on a graph and the best fit line was found. • Using the equation of the best fit line, we are able to predict the number of births, deaths and net migration for the subsequent years.

  17. Assumptions • All individuals have equal chance of contracting the disease. • The government does not implement or change policies which affect migration rates. • All variables have a trend that the model is able to predict.

  18. Obstacles Faced

  19. Data Collection - Climate • Precipitation and Temperature • Obtained on a daily basis – allowed for weekly periods to be found • Extracted from the US National Oceanic and Atmospheric Administration(NOAA) supported database • All data as recorded at the Singapore Changi Airport weather station

  20. Data Analysis – Climate • Extension • Connect the statistics obtained with number of new cases • Based on climate predictions, predict resulting fluctuations in the number of new cases

  21. Bibliography Academy of Science. Academy of Science Mathematics BC Calculus Text. Breish, N., & Thorne, B. (n.d.). Lyme disease and the deer tick in maryland. Maryland: The University of Maryland. Duane J. Gubler(1998, July). Clinical Microbiology Reviews, p. 480-496, Vol. 11, No. 3, 0893-8512/98/$00.00+0. Dengue and Dengue Hemorrhagic Fever. Retrieved November 3, 2010 from http://cmr.asm.org/cgi/content/full/11/3/480?view=long&pmid=9665979 Neuwirth, E., & Arganbright, D. (2004). The active modeler: mathematical modeling with Microsoft Excel. Belmont, CA: Thomson/Brooks/Cole Ministry of Health: FAQs. (n.d.). Dengue. Retrieved November 3, 2010, from http://www.pqms.moh.gov.sg/apps/fcd_faqmain.aspx?qst=2fN7e274RAp%2bbUzLdEL%2fmJu3ZDKARR3p5Nl92FNtJidBD5aoxNkn9rR%2fqal0IQplImz2J6bJxLTsOxaRS3Xl53fcQushF2hTzrn1PirzKnZhujU%2f343A5TwKDLTU0ml2TfH7cKB%2fJRT7PPvlAlopeq%2f%2be2n%2bmrW%2bZ%2fJts8OXGBjRP3hd0qhSL4

  22. Bibliography Ong, A., Sandar, M., Chen, M. l., & Sin, L. Y. (2007). Fatal dengue hemorrhagic fever in adults during a dengue epidemic in Singapore. International Journal of Infectious Diseases, 11, 263-267. Stafford III, K. (2001). Ticks. New Haven: The Connecticut Agricultural Experiment Station. Wei, H., Li, X., & Martcheva, M. (2008). An epidemic model of a vector-borne disease with direct transmission and time delay. Journal of Mathematical Analysis and Applications, 342, 895-908. Dobson, A. (2004). Population Dynamics of Pathogens with Multiple Host Species. The American Naturalist, 164, 564-578. Hii, Y. L., Rocklov, J., Ng, N., Tang, C. S., Pang, F. Y., & Sauerborn, R. (2009). Climate variability and increase in intensity and magnitude of dengue incidence in Singapore. Glob Health Action, 2. Retrieved April 23, 2011, from http://www.globalhealthaction.net/index.php/gha/article/view/2036/2590 Climate Data Online. (n.d.).NNDC Climate Data Online. Retrieved April 23, 2011, from http://www7.ncdc.noaa.gov/CDO/cdoselect.cmd?datasetabbv=GSOD&countryabbv=&georegionabbv=

  23. Thank You Any Questions?

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