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This study investigates the combined effects of TNF-related apoptosis-inducing ligand (TRAIL) and retinoic acid (RAc) on human colon polyps and intestinal stem cells (ISCs). By analyzing the cellular responses to these agents, the research aims to understand their potential roles in colon carcinogenesis and the regulation of ISC function. The findings suggest that TRAIL and RAc can influence cell survival and differentiation processes, providing insights into potential therapeutic strategies for colon cancer treatment.
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Effect of TRAIL and RAc on human colon polyps and ISCs. L Zhang et al.Nature000, 1-4 (2010) doi:10.1038/nature08871