Download
assignment of spin systems n.
Skip this Video
Loading SlideShow in 5 Seconds..
Assignment of Spin Systems PowerPoint Presentation
Download Presentation
Assignment of Spin Systems

Assignment of Spin Systems

206 Vues Download Presentation
Télécharger la présentation

Assignment of Spin Systems

- - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript

  1. Assignment of Spin Systems • For each compound: • Describe all spin systems • Determine the number of protons that are: • Chemical shift equivalent • Magnetic equivalent • Enantiotopic • Diastereotopic CHEM 430 – NMR Spectroscopy

  2. Splitting of Signals – Structure determination MW 114 MW 116 CHEM 430 – NMR Spectroscopy

  3. Splitting of Signals – Structure determination MW 169 has -Br MW 150 CHEM 430 – NMR Spectroscopy

  4. Splitting of Signals – Structure determination MW 100 MW 74 CHEM 430 – NMR Spectroscopy

  5. Splitting of Signals – Structure determination MW 73 MW 56 CHEM 430 – NMR Spectroscopy

  6. Splitting of Signals – Structure determination MW 89 MW 138 CHEM 430 – NMR Spectroscopy

  7. Splitting of Signals – Structure determination MW 122 MW 102 CHEM 430 – NMR Spectroscopy

  8. Splitting of Signals – Structure determination MW 113 MW 94 CHEM 430 – NMR Spectroscopy

  9. Splitting of Signals – Structure determination MW 152 MW 157 has -Cl CHEM 430 – NMR Spectroscopy

  10. Splitting of Signals – Structure determination MW 208 MW 98 CHEM 430 – NMR Spectroscopy

  11. Splitting of Signals – Structure determination MW 126 MW 116 CHEM 430 – NMR Spectroscopy

  12. Splitting of Signals – Structure determination MW 162 2 -Cl MW 122 CHEM 430 – NMR Spectroscopy

  13. Splitting of Signals – Structure determination MW 96 CHEM 430 – NMR Spectroscopy

  14. Practice with Pople Notation • On graph paper, draw a schematic (line) representation of the pure first-order spectrum AMX3corresponding to the following parameters: • n (Hz from TMS): nA = 80; nM = 220; nX= 320 • J (Hz): JAM = 10; JAX = 12; JMX = 0 • Assume spectrum is a pure 1st order spectrum and ignore small distortions in relative intensities that would occur in a ‘real’ spectrum. • Sketch in “splitting diagrams” above the schematic spectrum to indicate which splittings correspond to which coupling constants. • Give the shifts on the d scale corresponding to the above spectrum on a 60 MHz NMR (1H). CHEM 430 – NMR Spectroscopy

  15. Practice with Pople Notation AMX3 n (Hz from TMS): nA = 80; nM = 220; nX= 320 J (Hz): JAM = 10; JAX = 12; JMX = 0 CHEM 430 – NMR Spectroscopy

  16. Structure Determination with Pople Notation The 400 MHz 1H NMR spectrum of one of the following isomeric hydroxycinnamic acids is given below. Which one is it? Justify your answer based on chemical shift and coupling constants. CHEM 430 – NMR Spectroscopy

  17. Structure determination with Pople Notation CHEM 430 – NMR Spectroscopy