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Part V: How genes are regulated

Part V: How genes are regulated

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Part V: How genes are regulated

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  1. Part V: How genes are regulated Chapter 15: Gene Regulation in Prokaryotes Chapter 16: Gene Regulation in Eukaryotes

  2. Chapter 15: Gene Regulation in Prokaryotes

  3. Gene activity is regulated primarily at the level of transcription

  4. lactose operon (lac operon)

  5. Structure of lactose operon

  6. The action of CAP-cAMP complex in lac operon CAP ( catabolic gene activator protein) structure

  7. cAMP and CAP (catabolite activator protein)

  8. cAMP(饥饿信号) 细菌 哺乳类动物 与分解物基因激活物结合的蛋白(catabolite gene activator protein,CAP) 激活PK 导致细胞内一系列酶活性的改变 发挥作用

  9. The general condition of • regulation of gene expression • in prokaryotes • the change of environment • positive regulation & negative regulation

  10. negative regulation repressor of lac bind to operator Positive regulation CAP-cAMP complex

  11. trytophan operon (Trp operon ) a. Structure mechanism of regulation *negative regulation of repressor the structure of repressor attenuation

  12. Attenuator located in L gene,contains a  independent termination structure # the mechanism of attenuation

  13. 大肠杆菌 低Trp培养基 高Trp培养基 转录生成6720个AA的全长多顺反子mRNA 转录终止于L基因5’端140个AA