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Kevan Shokat , PhD

Kevan Shokat , PhD. Herman Suit Lecture CTOS 2013 New York, NY. Herman Suit, MD, DPhil, FASTRO. Organizational meeting 1993 CTOS 1 st meeting 1995 CTOS incorporated 1997. 2010. Kevan Shokat , PhD. Professor and Chair, Department of Cellular and Molecular Pharmacology, UCSF

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Kevan Shokat , PhD

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  1. KevanShokat, PhD Herman Suit Lecture CTOS 2013 New York, NY

  2. Herman Suit, MD, DPhil, FASTRO Organizational meeting 1993 CTOS 1st meeting 1995 CTOS incorporated 1997 2010

  3. KevanShokat, PhD • Professor and Chair, Department of Cellular and Molecular Pharmacology, UCSF • Professor of Chemistry, UC Berkeley • HHMI Scientist, 2005- • National Academy of Sciences, 2010 • BA Chemistry, Reed College, 1986 • PhD Chemistry, UC Berkeley, 1991 (P. G. Shultz) • Postdoc-C.C. Goodnow 1992-4 • Princeton 1994-1999 • UC Berkeley and UCSF 1999- (Professor: 2001)

  4. PhD years Nature 1989; 338: 269

  5. By exploiting the highly conserved nature of the ATP binding site across the kinase superfamily and the availability of structural information from other protein kinases, we were able to engineer novel substrate specificity for v-Src without any detailed structural information about v-Src itself. That we used an unrelated kinase as a blueprint for designing orthogonal ATP analogs to tag the direct cellular substrates of v-Srcsuggests that this approach should work for other kinases as well. If it does, then it might be possible to systematically begin to dissect the complex proximal signaling cascades controlled by cellular tyrosine kinases.

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