1. IMMUNIZATION INITIATIVEFOR THE AGING:A TIME FOR ACTION?MICHAEL WALDHOLZPULITZER-PRIZE WINNING HEALTH JOURNALIST

2. VACCINE INITIATIVES ON THE RISE • VACCINES AS GLOBAL TOOL FOR COST-EFFECTIVE DISEASE PREVENTION •  THE DECADE OF VACCINES COLLABORATION • 10-Year Global Vaccine Action Plan – 2012 World Health Assembly Presentation • THE GAVI ALLIANCE MODEL FOR INCREASING VACCINE COVERAGE FOR CHILDREN • INDUSTRY INNOVATION • GROUP OF EIGHT (G8) REAFFIRMS SUPPORT FOR GAVI APPROACH • UN-WHO World Health Day on Aging, April 2012

3. “In the same way that during my Microsoft career I talked about the magic of software, I now spend my time talking about the magic of vaccines. They are the most effective and cost-effective health tools ever invented. I like to say vaccines are a miracle’’ Bill Gates, The Bill & Melinda Gates Foundation

4. THE GAVI MODEL 2000-2012 • 326 Million Additional Children Immunized • Prevented Death of 5 Million Children • Gates Commitment • $10 Billion over Next 10 Years to Prevent 7.6 Million Additional Deaths by 2019 • Unique Financing • $7.2 Billion Pledged Since 2000 • $3.6 Billion Raised in Capital Markets • Innovative Vaccine Production Incentives • Low-Priced Vaccine Production by Additional Countries China, Brazil, Russia, India • Vaccines Procured at Significant Discount

5. VACCINES FOR THE AGING • Influenza • Pneumococcal • Shingles (Herpes Zoster) • Diphtheria Tetanus Pertussis (DPT) • Yellow Fever • Malaria • Alzheimer’s Disease

6. DEMOGRAPHIC EXPLOSION 2010-2040 In Richer Nations • Aged 65-70 to Rise to 207 Million from 142 Million • Over Age 80 to Double to 105 Million In Developing Nations • Aged 65-70 to Triple to 752 million • Over Age 80 to Quadruple to 198 million 80% of World’s 60+ Population will be in Lower/Middle-Income Nations

7. NEED FOR INCREASED VACCINE COVERAGE FOR AGING • Compromised health status of aging populations Decreased Immune Function Co-Morbidities • Cost US: 2010 Pneumonia-Related Costs at $5.5 Billion Europe: Estimated at 10 Billion Euros • ``Little Progress In Improving Adult Coverage in Past Year Highlights Need for Efforts to Increase Coverage’’ 2011 Report by US Centers for Disease Control • Global Vaccine Action Plan Presented to World Health Assembly  ``Life Course’’ Approach Recommended though Focus Mostly on Childhood Immunization • Pneumococcal Vaccine Coverage in US for Over 65 is 60% • Initiatives Aimed Mostly at Childhood Coverage

8. PROVEN BENEFIT OF VACCINE CAMPAIGNS • Seattle: 10-YEAR Influenza Campaign • 27% at risk of influenza • Results: 48% reduction in death • Turkey: Increased Coverage Rate to 40-60% from 2% • Results: Gain in Life-Years, Reduced Hospitalizations • Spain: Influenza Vaccine Campaign • Results: Employee Absenteeism Reduced 23% • One Euro Invested Saved Four Euros in Absenteeism Costs • Additional Benefits • Herd Immunity • Innovation Encouraged • Lower-Priced Vaccines

9. POTENTIAL FUTURE INITIATIVES • New Studies Needed to Show Cost-Benefit and Mortality and Morbidity Benefit • Physician Outreach and Tracking • Health Department Initiatives • Public Awareness • GAVI-like Initiative and Gates-like Champion • Industry Action – Innovation, Pricing • Global-Regional Calls to Action