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Investigating the Role of p16 and CDK4 in Latent HIV Infection in LTNP Individuals

This study explores the molecular mechanisms involving p16 and cyclin-dependent kinase 4 (CDK4) in individuals classified as long-term non-progressors (LTNP) infected with HIV. Using 293T cell line models and Western blotting (WCE), we examine the expression levels of p16 and its interactions with specific proteins including HAART. Our findings aim to provide insights into the negative regulatory pathways that maintain viral latency and could inform future therapeutic strategies for HIV management.

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Investigating the Role of p16 and CDK4 in Latent HIV Infection in LTNP Individuals

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  1. A) C) Negative HAART LTNP 293T WCE α-p16 Low LTNP L H L H L H A + α-IgG α-p16 HP1γ A 1 2 3 4 5 6 2 3 p16 p16 cdk4 1 2 3 4 5 6 7 8 9 10 PCTAIRE HP1α 1 2 3 4 5 6 High LTNP Low LTNP B) 293T WCE 293T WCE 1 2 3 4 5 6 1 2 3 4 5 6 D A p16 cdk4 1 2 3 4 5 6 7 8 1 2 3 4 5 6 7 8

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