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Dengue Fever

Dengue Fever

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Dengue Fever

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  1. Dengue Fever Amber Beg April 6, 2010 Biology 402 http://www.mosquitoage.org/Portals/12/Images/dengue%20virus_em.jpg

  2. Dengue is a tropical febrile disease http://gamapserver.who.int/mapLibrary/Files/Maps/World_DengueTransmission_Extension_2008.png

  3. Dengue Fever has a long history… www.philadelphia-reflections.com/topic/17.htm 992- Chinese Encyclopedia 1780- Philadelphia “break-bone fever” Benjamin Rush

  4. Isolated by Albert Sabin in 1944 http://www.notablebiographies.com/images/uewb_09_img0622.jpg

  5. …and become a MAJOR pandemic in the last 50 years Endemic in more than 1oo countries 2.5 billion people at risk www.tatterhood.com/category/gameart/tastyplanet

  6. How is it spread?? THE VECTOR: Aedes aegypti http://www.metapathogen.com/IMG/Aedes-aegypti.jpg

  7. Ae. aegypti likes humans and our products http://www.bviplatinum.com/images/articleimg/6442b.jpg

  8. Spread of the vector and the disease go hand in hand www.latinamericanstudies.org/Transatlantic.htm Transatlantic Slave Trade World War II http://neatorama.cachefly.net/images/2007-09/world-war-2.jpg

  9. Why such a problem?? • Ineffective mosquito control • Rapid population growth • Non-biodegradable packaging • Rapid increase in air travel http://farm1.static.flickr.com/81/285601911_f859e04e39.jpg

  10. So how do I know if I have it? • Fever • Rash • Severe headache • Musculoskeletal pains http://www.microbiologybytes.com/blog/2008/05/

  11. Sounds a lot like the flu…

  12. The Real Problem: Dengue Hemorrhagic Fever • Symptoms: • Plasma leakage • Hepatomegaly • Low blood pressure • Hypovolemic shock • Death

  13. There is no specific treatment for DHF http://www.health-res.com/EX/08-01-15/82560-main_Full.jpg Can only treat the symptoms

  14. There are 4 viral serotypes • Family Flaviviridae • Same family as Yellow Fever http://www.microbiologybytes.com/virology/3035pics/dengue.jpg

  15. Dengue is an RNA Virus Single strand positive RNA Genome Envelope Virus too! http://www.microbiologybytes.com/blog/2007/10/23/dengue-virus-infection-activates-the-unfolded-protein-response/

  16. Secondary infections tend to produce DHF…. Antibodies enhance viral replication!

  17. How can we stop it? Mosquito control: Improved water storage Insecticides Introduction of mosquito-eating fish and copepods

  18. Even Better: A Vaccine • Tetravalent live attenuated • Intertypic chimaeric vaccine • Chimaeric vaccine Nothing yet but progress is being made http://thefreemarketeers.files.wordpress.com/2009/07/syringe2.jpg

  19. Works Cited "Dengue." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 16 Mar. 2010. Web. 30 Mar. 2010. <http://www.cdc.gov/Dengue/>. Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention, and Control. 2nd ed. Geneva: World Health Organization, 1997. Print. "Dengue." World Health Organization. World Health Organization. Web. 30 Mar. 2010. <http://www.who.int/topics/dengue/en/>. Gubler, D. J., and GoroKuno, eds. Dengue and Dengue Hemorrhagic Fever. Wallingford, Oxon, UK: CAB International, 1997. Print. Mandell, Gerald L., John E. Bennett, and Raphael Dolin. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 7th ed. New York: Elsevier/Churchill Livingstone, 2010. Print. Mustafa, Maj, and V. K. Agrawal. "Dengue Vaccine: The Current Status." Medical Journal Armed Forces India 64.2 (2008): 161-64. Web. Rothman, Alan L. "Dengue: Defining Protective versus Pathologic Immunity." The Journal of Clinical Investigation 113.7 (2004): 946-51. Web.