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Genetics 210: Personalized Medicine and Genomics

Genetics 210: Personalized Medicine and Genomics. For: MDs, PhDs and curious students Spring term. Tue 2:15 – 4:05 Thur. 2:15-4:05 Genotyping : $15 copay Gene210.stanford.edu: info and FAQs. Today. Course overview (~30’) Informed consent (~30’) How to get genotyped (~10’)

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Genetics 210: Personalized Medicine and Genomics

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  1. Genetics 210: Personalized Medicine and Genomics For: MDs, PhDs and curious students Spring term. Tue 2:15 – 4:05 Thur. 2:15-4:05 Genotyping : $15 copay Gene210.stanford.edu: info and FAQs

  2. Today Course overview (~30’) Informed consent (~30’) How to get genotyped (~10’) Questions (~15’)

  3. Course Staff • Course Organizers: • Stuart Kim (Dev. Bio., Genetics) • Aaron Gitler (Genetics) • Rosalind Chuang (Neurology) • TAs: • Andrew Roos (Epidemiology) • Thomas Roos (Epidemiology)

  4. Published Genome-Wide Associations

  5. Genetics 210: Personalized Medicine and Genomics Diabetes Heart Disease Cancer Alzheimer’s, Parkinson’s/Huntington’s

  6. Human Ancestry

  7. Height prediction

  8. How much Neanderthal are you? George Church, Harvard Geneticist Neanderthal

  9. Stuart All time record

  10. Joint Genotyping Task Force • 2008-2010 • Charles Prober Dean Hank Greely Law School • Russ Altman Genetics C. Braddock Med School • Pat Brown Biochem. Gil Chu Biochem • Mike Grecius Neur. Sean David Med. School • Carlos Bustamente Gen. Harry Greenberg Dean • Ralph Horwitz Psych Louanne Hudgins Epi • Anne James Legal Counsel Jesse Karmazin Med. School • Stuart Kim Dev. Bio. Mark KrasnowBiochem • Phil Lavori HRP David Magnus Cen. BME • Kelly Ormond Genetics Alan Schatzberg Psych. • Mike Snyder Genetics Atul Butte BMI • KeyanSalari Med. School Mildred Cho Pediatrics

  11. Personal Genotyping Voluntary. You can use a public genome file instead of your own. Confidential – instructors will not know who opted to be genotyped. Private – Your own DNA information will not be revealed. Counseling - genetic counseling via 23andMe and medical/psychological counseling via Dr. Alan Schatzberg (Psychology, Stanford).

  12. Introductory Projects Report on specific genetic locus. Published on SNPedia.com Class room debate on FDA legislation Unanticipated opportunities that arise as you explore your genome

  13. Advanced Projects = (project + final) Annotate whole-genome for Stuart Kim or Aaron Gitler (adopted) Write a grant for Kaiser-Permanente GWAS (n=110,000) Analyze exome sequence data from ALS patients Write an algorithm for choosing minimal n number of people to sequence to get all sequence data in a population

  14. Gene210 Three Manuscripts Textbook Patent Grant iPhone App in the news Chicago Medicine Magazine (story on page 18) Salon Web Magazine (9/2013) Stanford Medicine - DNA testing improves learning (8/13) San Jose Mercury News (5/2013) Time (2/2013) Nature USA Today San Francisco Chronicle Recap San Francisco Chronicle Genome Technology Stanford Press Release Nature Blogs LA Times Blog Genome Web Center for Genetics and Society Scientific American

  15. Exploring Personal GenomicsAvailable at Amazon.com

  16. How to get genotyping kits Attend this information session. Make check $15 to Stanford. Bring check to Kathy Fisher in Beckman B300. Fill out informed consent form Bring samples back to Kathy B300 We will ship the group of samples back to company Tuesday 4pm Feb. 4 Results in 6-8 weeks. Class starts Tuesday April 1, 2012.

  17. https://www.23andme.com/user/claim/

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