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Fat pad weight (g)

Figure 1. b. a. **. 5. 120. **. 100. 4. 80. 3. ATX mRNA/18SRNA. **. Fat pad weight (g). 60. **. NS. 2. 40. NS. 1. 20. 0. 0. Db/db. GTG. HFD. Db/db. GTG. HFD. c. d. **. **. 6. 4.5. 4.0. 5. 3.5. *. **. 4. 3.0. 2.5. Plasma glucose (g/l).

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Fat pad weight (g)

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  1. Figure 1 b a ** 5 120 ** 100 4 80 3 ATX mRNA/18SRNA ** Fat pad weight (g) 60 ** NS 2 40 NS 1 20 0 0 Db/db GTG HFD Db/db GTG HFD c d ** ** 6 4.5 4.0 5 3.5 * ** 4 3.0 2.5 Plasma glucose (g/l) Plasma Insulin (ng/ml) 3 * 2.0 * 2 1.5 1.0 1 0.5 0 0 Db/db GTG HFD Db/db GTG HFD

  2. a Figure 2 ** 8 6 Plasma glucose (g/l) 4 2 0 Cont strepto b 600 500 400 Fat pad weight (mg) ** 300 200 100 0 Cont strepto c 70 NS 60 50 ATX mRNA /18S RNA 40 30 20 10 0 Cont strepto

  3. a d ** ** ** 3.0 ** ** 120 2.5 100 ** 2.0 80 ** ATX mRNA / 18S RNA Fat Pad Weight (g) 1.5 60 1.0 40 0.5 20 0.0 0 4 5 6 7 8 9 10 11 12 4 5 6 7 8 9 10 11 12 Age (weeks) Age (weeks) b ** ** 7.0 ** ** ** 6.0 ** 5.0 4.0 Plasma Insulin (ng/ml) 3.0 2.0 1.0 0.0 4 5 6 7 8 9 10 11 12 Age (weeks) c Figure 3

  4. ING PG Figure 4 b a ** 200 200 ** 160 160 120 120 ATX mRNA / 18S RNA ATX mRNA / 18S RNA 80 80 40 40 0 0 PG ING Adipocytes Stroma-vascular cells

  5. Figure 5 *** 18 16 14 *** 12 10 Glucose uptake (nmol 2DG/100 mg lipid/10 min) 8 6 4 * 2 0 basal insulin Basal insulin basal insulin HFD Cont db/db

  6. Figure 6 * 1000 900 800 700 600 500 ATX mRNA / 18S RNA 400 ** 300 ** 200 100 0 Cont TNF rozi TNF + rozi

  7. 0 1 2 3 4 [14C]LPC [14C]LPA depot Figure 7 b a MW (kDa) 1 2 3 4 183 114 81 64

  8. Figure 8 50 45 P<0.034 40 35 30 ATX mRNA / 18S RNA 25 20 15 10 5 0 NGT IGT-D

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