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ORNL–University Partnerships in Computational Biology

ORNL–University Partnerships in Computational Biology. Igor B. Jouline Joint Institute for Computational Sciences The University of Tennessee–Oak Ridge National Laboratory. ORNL–University partnerships in computational biology. • Joint Institute for Biological Sciences.

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ORNL–University Partnerships in Computational Biology

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  1. ORNL–University Partnerships in Computational Biology Igor B. Jouline Joint Institute for Computational Sciences The University of Tennessee–Oak Ridge National Laboratory

  2. ORNL–University partnerships in computational biology • Joint Institute for Biological Sciences • Joint Institute forComputational Sciences • Graduate School of Genome Science and Technology • School of Biology • College of Computing • Center for Bioinformatics and Computational Biology • Biosciences Division • Computer Science and Mathematics Division

  3. ORNL–UT Graduate School of Genome Science & Technology Areas of Research and Education: Genetics and Genomics Structural Biology and Proteomics Computational Biology and Bioinformatics http://gst.ornl.gov

  4. PostgreSQL relational database management system SMART libraries Signal transduction families — MiST HHMER Pfam libraries Signal transduction families signatures MiST: Microbial Signal Transduction Database Genomes Meta- genomics (in progress) Modular Perl infrastructure XML SQL Linux Web interface Protein sequences Domain architectures http://genomics.ornl.gov/mist

  5. MiST: Visualization of signal transduction profiles in 176 microbial genomes http://genomics.ornl.gov/mist

  6. Distribution of sensory (a) and regulatory (b) domains in microbial genomes Ulrich et al. (2005) Trends Microbiol

  7. Computational microbial genomics: Poison + water = hydrogen Life in Hot Carbon Monoxide: The Complete Genome Sequence of Carboxydothermus hydrogenoformans Z-2901 Martin Wu, Qinghu Ren, A. Scott Durkin, Sean C. Daugherty, Lauren M. Brinkac, Robert J. Dodson, Ramana Madupu, Steven A. Sullivan, James F. Kolonay, William C. Nelson, Luke J. Tallon, Kristine M. Jones, Luke E. Ulrich, Juan M. Gonzalez, Igor B. Zhulin, Frank T. Robb, and Jonathan A. Eisen "The findings show the continued value of microbial genome sequencing for exploring the useful capabilities of the vast realm of microbial life on Earth,"says Ari Patrinos, former director of the Office of Biological and Environmental Research, part of the U.S. Department of Energy's (DOE) Office of Science. DOE, which funded the study, is pursuing clean fuel technologies. www.sciencedaily.com/releases/2005/12/051204103616.htm

  8. Contacts Igor B. Jouline (Zhulin) PhD. Joint Institute for Computational SciencesThe University of Tennessee — Oak Ridge National Laboratory Associate Professor The University of Tennessee UTK (865) 974-7687 Ijouline@utk.edu Senior R&D Staff MemberOak Ridge National Laboratory ORNL (865) 241-3697 joulineib@ornl.gov 8 Jouline_Bio_0611

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