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The hypothalamo-pituitary axis. petercelec@gmail.com. Hypothalamus. Nervous regulation of the autonomous nervous system – adrenal medulla Production of ADH and oxytocin supraoptical and paraventricular nuclei neurophysin Regulation of hormone production in the pituitary grand.

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## The hypothalamo-pituitary axis

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**The hypothalamo-pituitary axis**petercelec@gmail.com**Hypothalamus**• Nervousregulationoftheautonomousnervoussystem – adrenalmedulla • Productionof ADH and oxytocin • supraoptical and paraventricularnuclei • neurophysin • Regulationofhormoneproduction in thepituitary grand**Hypothalamus**• Liberins • CRH (ACTH), TRH (TSH), GHRH (GH), GnRH (LH, FSH), Salsolinol (PRL) • Statins • Somatostatin (GH), Dopamin (PRL)**Prolactin functions**• Lactation • Immunomodulation? • Behavior? • Water and electrolyte balance? • Metabolism? • Reproduction?**GH**• Overproduction of GH • Gigantism • Acromegaly • GH deficiency • Nanism • GH deficiency sy • Somatopause**ADH disorders**• Deficiencyof ADH • Diabetes insipidus • Polydipsia, polyuria • Central • Renal • Overproductionof ADH • Syndromeof IAD • Hypoosmolalityofplasma, hyponatriemia, oliguria**Hypopituitarism**• General • Selective • Trauma, infection, hemorrhage , tumors... • Inborn errors • Therapy - supplementation**Sheehan's syndrome**• Intra-partum infarction of the pituitary gland • mother & child • GH – LH/FSH – TSH • Consequences?**Discussion**• Journalinfo, authorinfo? • Aim? • Objects? • Methods? • Main results? • Limitations? • Application? • Conclusions?

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