1. The hypothalamo-pituitary axis petercelec@gmail.com

5. Hypothalamus • Nervousregulationoftheautonomousnervoussystem – adrenalmedulla • Productionof ADH and oxytocin • supraoptical and paraventricularnuclei • neurophysin • Regulationofhormoneproduction in thepituitary grand

7. Hypothalamus • Liberins • CRH (ACTH), TRH (TSH), GHRH (GH), GnRH (LH, FSH), Salsolinol (PRL) • Statins • Somatostatin (GH), Dopamin (PRL)

8. Overview

9. GnRH

10. GHRH

13. Prolactin

14. Prolactin functions • Lactation • Immunomodulation? • Behavior? • Water and electrolyte balance? • Metabolism? • Reproduction?

15. CRH

16. TRH

17. ADH - vasopressin

18. ADH - vasopressin

19. Oxytocin

20. Oxytocin

21. ADH & oxytocin

22. Pathology

23. GH • Overproduction of GH • Gigantism • Acromegaly • GH deficiency • Nanism • GH deficiency sy • Somatopause

26. ADH disorders • Deficiencyof ADH • Diabetes insipidus • Polydipsia, polyuria • Central • Renal • Overproductionof ADH • Syndromeof IAD • Hypoosmolalityofplasma, hyponatriemia, oliguria

27. Hypopituitarism • General • Selective • Trauma, infection, hemorrhage , tumors... • Inborn errors • Therapy - supplementation

28. Sheehan's syndrome • Intra-partum infarction of the pituitary gland • mother & child • GH – LH/FSH – TSH • Consequences?

29. Discussion • Journalinfo, authorinfo? • Aim? • Objects? • Methods? • Main results? • Limitations? • Application? • Conclusions?