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Understanding KChIP-1 Protein Function in Ion Channel Regulation

KChIP-1 is a regulatory subunit of Kv4/D-type voltage-gated ion channels, part of an octamere, and binds to Calcium ion. It plays a crucial role in repolarizing axons by pumping K+ ions out of the cell membrane. Discover the intricate structure of KChIP1-Kv4.3 T1 complex where the proteins interact.

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Understanding KChIP-1 Protein Function in Ion Channel Regulation

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  1. Kv Channel-interacting protein 1 (KChIP-1) NileshJambhekar

  2. Function: • It is a regulatory subunit of Kv4/D (Shal)-type voltage-gated ion channels. • It is part of an Octamere of 4 Kv4/D subunits and 4 KChIP1 subunits. • It binds to the Calcium ion. • In the Kv4.2 N terminus, residues 7-11 and 71-90, are necessary for KChIP1 to regulate Kv4.2. • It “accelerates recovery” (repolarizes axon)” by causing Kv4/D to pump K+ ions out of the cell membrane.

  3. Structure: KChIP1–Kv4.3 T1 complex  The inside Kv.4.3 protein spiral is a hydrophobic area covered by the KChiP1 protein. Also notice the Kv4.3 protein is extending into the KChIp1 protein.

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