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Effect of renin-angiotensin system blockade on calcium channel blocker-associated peripheral edema Makani H et al. Am

Effect of renin-angiotensin system blockade on calcium channel blocker-associated peripheral edema Makani H et al. Am J Med. 2011;124:128-135,. METHOD:

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Effect of renin-angiotensin system blockade on calcium channel blocker-associated peripheral edema Makani H et al. Am

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  1. Effect of renin-angiotensin system blockade on calcium channel blocker-associated peripheral edemaMakani H et al. Am J Med. 2011;124:128-135, METHOD: • A MEDLINE/COCHRANE search for randomised controlled trials (RCT) in patients with hypertension, comparing calcium channel blocker (CCB) monotherapy with CCB/renin angiotensin system blocker combination conducted from 1980. • RCTs reporting the incidence of peripheral edema or withdrawal of patients because of edema and total sample size more than 100 were included in this analysis. • 25 RCTs with 17,206 patients (mean age 56 years, 55% were men) and a mean duration of 9.2 weeks. .

  2. Combining RAAS inhibitors with CCB decreases edema incidence/withdrawal rates with CCB Percentage CCB = calcium channel blocker; RAS = renin-angiotensin system *p<0.0001 Makani H et al. Am J Med. 2011;124:128-135

  3. ACE inhibitors are more efficaciousthanARBs in reducing CCB-associated edema P=0.0001 P<0.00001 Makani H et al. Am J Med. 2011;124:128-135

  4. Clinical significance Makani H et al. Am J Med. 2011;124:128-135. The combination of RAAS inhibitors with calcium channel blockers (CCB) reduces the incidence by 38% and withdrawal rate due to peripheral edema by 62% when compared with calcium channel blocker monotherapy. ACE inhibitors were significantly more efficacious than ARBs in reducing the incidence of CCB-associated peripheral edema by 54% and 24%, respectively (P<0.0001), Aliskiren did not show significant reduction of CCB-associated cough.

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