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Antihypertensive Trial Outcome Differences: Diuretic vs. Calcium Channel Blocker

2. Antihypertensive Trial Outcome Differences: Diuretic vs. ACE Inhibitor. Compared to participants assigned to the diuretic, those assigned to the ACE inhibitor had:2 mm Hg higher SBP and no change in DBP overall4 mm Hg higher SBP and 1 mm Hg higher DBP in BlacksNo difference in CHD or total mo

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Antihypertensive Trial Outcome Differences: Diuretic vs. Calcium Channel Blocker

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    1. 1 Antihypertensive Trial Outcome Differences: Diuretic vs. Calcium Channel Blocker Compared to participants assigned to the diuretic, those assigned to the calcium channel blocker had: 1 mm Hg higher SBP and 1 mm Hg lower DBP No difference in CHD, total mortality, stroke, or combined CVD 38% higher risk of heart failure 35% higher risk of hospitalization for heart failure The three core messages for the ALLHAT antihypertensive trial are: Diuretics should be the drug of choice for first step therapy of hypertension For the patient who cannot take a diuretic (which should be an unusual circumstance), CCBs and ACEIs may be considered. Most hypertensive patients require more than one drug. Diuretics should generally be part of the antihypertensive regimen. Lifestyle advice should also be provided. The three core messages for the ALLHAT antihypertensive trial are: Diuretics should be the drug of choice for first step therapy of hypertension For the patient who cannot take a diuretic (which should be an unusual circumstance), CCBs and ACEIs may be considered. Most hypertensive patients require more than one drug. Diuretics should generally be part of the antihypertensive regimen. Lifestyle advice should also be provided.

    2. 2 Antihypertensive Trial Outcome Differences: Diuretic vs. ACE Inhibitor Compared to participants assigned to the diuretic, those assigned to the ACE inhibitor had: 2 mm Hg higher SBP and no change in DBP overall 4 mm Hg higher SBP and 1 mm Hg higher DBP in Blacks No difference in CHD or total mortality 15% higher risk of stroke 40% higher risk of stroke for Blacks The three core messages for the ALLHAT antihypertensive trial are: Diuretics should be the drug of choice for first step therapy of hypertension For the patient who cannot take a diuretic (which should be an unusual circumstance), CCBs and ACEIs may be considered. Most hypertensive patients require more than one drug. Diuretics should generally be part of the antihypertensive regimen. Lifestyle advice should also be provided. The three core messages for the ALLHAT antihypertensive trial are: Diuretics should be the drug of choice for first step therapy of hypertension For the patient who cannot take a diuretic (which should be an unusual circumstance), CCBs and ACEIs may be considered. Most hypertensive patients require more than one drug. Diuretics should generally be part of the antihypertensive regimen. Lifestyle advice should also be provided.

    3. 3 Antihypertensive Trial Outcome Differences: Diuretic vs. ACE Inhibitor Compared to participants assigned to the diuretic, those assigned to the ACE inhibitor had: 10% higher risk of combined CVD outcome 19% higher risk of combined CVD outcome in Blacks 6% higher risk of combined CVD outcome in non-Blacks 11% higher risk for being hospitalized or treated for angina 10% higher risk for undergoing coronary revascularization 19% higher risk of heart failure The three core messages for the ALLHAT antihypertensive trial are: Diuretics should be the drug of choice for first step therapy of hypertension For the patient who cannot take a diuretic (which should be an unusual circumstance), CCBs and ACEIs may be considered. Most hypertensive patients require more than one drug. Diuretics should generally be part of the antihypertensive regimen. Lifestyle advice should also be provided. The three core messages for the ALLHAT antihypertensive trial are: Diuretics should be the drug of choice for first step therapy of hypertension For the patient who cannot take a diuretic (which should be an unusual circumstance), CCBs and ACEIs may be considered. Most hypertensive patients require more than one drug. Diuretics should generally be part of the antihypertensive regimen. Lifestyle advice should also be provided.

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