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Specific Mutation Induced by Triplex-Forming Oligouncleotides in Mice

Specific Mutation Induced by Triplex-Forming Oligouncleotides in Mice. Karen M. Vasquez, Latha Narayanan, Peter M. Glazer. 20 October 2000 Science Date: 2001 4/25 Speaker: 劉育男. Introduction:. ~Aptamer. ~SELEX.

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Specific Mutation Induced by Triplex-Forming Oligouncleotides in Mice

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  1. Specific Mutation Induced by Triplex-Forming Oligouncleotides in Mice Karen M. Vasquez, Latha Narayanan, Peter M. Glazer 20 October 2000Science Date: 2001 4/25 Speaker: 劉育男

  2. Introduction: ~Aptamer ~SELEX

  3. Triplex-Forming Oligonucleotide (TFOs)

  4. TFO發展面臨的問題 1.Cell uptake 2.Stability of TFO 3.Specific targeting site or potential site 4.New DNA damage agent 5.Triplex-binding code

  5. Conclusion: These studies established that small DNA molecule can be administered by i.p. or intravenous injection and gain access to tissue and to cell nuclei Chromosomal DNA throughout the somatic tissues of an animal can be targeted by nucleic acid aptamers

  6. Aptamers的應用 ~取代antibodies 作為更專一性的結合ligand Medical usage, Lab usage ~調控Cell bioactivities Drug design

  7. The End Thank you

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