1 / 14

Organic Antioxidation a novel approach.. ….QUADRACARE

Learn about the role of Vitamin E and Selenium in combating free radicals that damage cell membranes, leading to various poultry health issues. Discover the mechanism of action and benefits of Vitamin E and Selenium supplementation, addressing deficiencies and improving poultry immunity. Uncover the importance of Selenoproteins and the superior effects of Vitamin E and Selenium combination for breeders. Explore how Vitamin E enhances cellular integrity of immune cells, aiding in immunity improvement.

dariust
Télécharger la présentation

Organic Antioxidation a novel approach.. ….QUADRACARE

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Organic Antioxidationa novel approach.. ….QUADRACARE

  2. Free Radicals Free radicals damage the cell membrane A. Healthy membrane B. Damaged membrane

  3. Vitamin E and Selenium Mechanism of action Se Vit.E

  4. Increased demand for Vitamin E and Selenium….. • A challenge to boost immunity • Stressful environment • Invariable contamination of mycotoxins • High infectious pressure • Faster and more efficient weight gain has increased the requirement • Wide variation in vit. E and Se content of feed stuff • Decreased availability (Selenium : Soyabean – 0.13 ppm & corn – 0.3 ppm) • Greater use of fat as energy source has created greater risk of peroxides

  5. Vitamin E and Selenium Deficiency-related problems Poultry • Impaired immunity • Exudative diathesis • Leg weakness, ascites • Slow feather growth • Increased drip loss • Poor weight gain & FCR • Impaired fertility • Embryonic death, etc.

  6. Selenium metabolism Se+4 Se-2 Seleno amino acids KIDNEY Small intestine Urine LIVER Selenoprotein formation Bile feces Muscle, milk and other tissues

  7. SELENIUM • Thyroid metabolism • Better growth • Stress tolerance • Anti-oxidant • Muscle integrity • Better meat qualtiy • Decreased drip loss • Improved fertility Selenoproteins • Sperm structure • Fertility • Hatchability • Immunity • Phagocytic ability of PMN cells • Vaccination titers • CMI

  8. Superiority of Vit.E & Se combination Breeders : Vitamin E and Selenium • Sparing effect on vitamin E • Higher vitamin E content of egg yolk • Higher vitamin E content of liver • Higher concentration in chick’s brain • Higher vitamin E in blood of chick • Increased anti-oxidant protection of chick • Higher GSH activity at hatch • Decreased mortality • Better immune response

  9. NEVER ENDING PROBLEMS • Today’s wide spread outbreaks of CCRD and other respiratory complexes • COCCIDIOSIS despite of anticoccidial usage • Salmonella & E.coli taking upperhand • Untracked mortalities specially in first week …….. All due to immunosuppression

  10. virus Bacteria Humoral Phagocytosis WBC Salmonella CMI Mycoplasma Immuno suppressionSilent killer

  11. Vitamin E improves cellular integrity of immune cells Immunity Cellular Macrophages Eosinophils Cytokines Antibodies Lymphocytes Cytokines B cells T cells Humoral Cellular HI CMI Acquired Immunity

  12. ImmunosupressionA Silent killer… • Disease susceptibility • Vaccination failures • Misleading diagnosis • Complicating the therapy • Poor performance Adding fuel to the fire……. • Frequent antibiotic resistance • High infectious pressure • Unavoidable stress

  13. Vitamin E and immunity • Chicks raised on diet with Vit. E showed better CMI • Chicks supplemented with Vit.E showed lower coccidial cecal lesions • Deficiency of Vit.E and Se depressed bursal weight & lymphocyte count in spleen • Supplementation of Vit.E reduced mortality in severe IBD and E.coli infections • Vit.E supplementation before ND / IBD vaccination resulted in improved HI titer • Better transfer of passive immunity was observed with Vit.E supplementation

  14. How Vit.E & Se improve immunity ? • Protect most vulnerable, rapidly proliferating cells of immune system from oxidative damage • Inhibition of prostaglandin – PGE production • Better antigen recognition • Favour the proliferation of T-cells • Balance between T-cells and macrophages

More Related