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N E U R O A N A L Y S I S

N E U R O A N A L Y S I S. neuroanalysis.org.il. Doctor, I am depressed, and sad. What do I have, doctor? Please tell me. You have depression. Doctor, my stomach hurts. What do I have, doctor ? Please tell me. You have gastritis. Doctor, I am depressed,

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N E U R O A N A L Y S I S

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  1. N E U R O A N A L Y S I S neuroanalysis.org.il

  2. Doctor, I am depressed, and sad. What do I have, doctor? Please tell me. You have depression.

  3. Doctor, my stomach hurts. What do I have, doctor ? Please tell me. You have gastritis. Doctor, I am depressed, and sad. What do I have, doctor? Please tell me. You have depression.

  4. Doctor, my stomach hurts. What do I have, doctor? Please tell me You have gastritis. Place in the body What happened to it? It is infected How to treat it Antibiotics Doctor, I am depressed, and sad. What do I have, doctor ? Please tell me. ? You have depression. ? ?

  5. …. “we are at the epicycle stage of psychiatry where astronomy was before Copernicus and biology before Darwin”…. Allen Frances

  6. NeuroAnalysis Rational Neuroscience

  7. NeuroAnalysis Rational Phenomenology Neuroscience

  8. NeuroAnalysis Rational Phenomenology Neuroscience Enormous gap The clinician sees a patient not neuronal networks or neurotransmitters

  9. NeuroAnalysis Rational Phenomenology Neuroscience Enormous gap The clinician sees a patient not neuronal networks or neurotransmitters

  10. NeuroAnalysis Rational Why we failed ? Phenomenology Neuroscience

  11. NeuroAnalysis Rational Why we failed ?

  12. NeuroAnalysis Rational Where did we fail? Ignoring complexity

  13. NeuroAnalysis Rational Proposed RDoC

  14. NeuroAnalysis Rational Clinical Brain Profiling CBP

  15. NeuroAnalysis Rational Clinical Brain Profiling CBP Explanatory power

  16. NeuroAnalysis Rational Clinical Brain Profiling CBP For example DISC1

  17. NeuroAnalysis Rational Clinical Brain Profiling CBP Future intervention power cure Optogenetics

  18. NeuroAnalysis Rational Clinical Brain Profiling CBP Translation matrix

  19. NeuroAnalysis Rational Phenomenology Sign 1 Sign 2 Sign 3 Sign 4 Sign 5 Sign 6 Sign N Symptom 1 Symptom 2 Symptom 3 Symptom 4 Symptom 5 Symptom N Neuroscience Cs Disconnection Ci Over connection De-optimization Hyper-optimization Constrain frustration Disturbed DMN

  20. NeuroAnalysis Rational Phenomenology Sign 1 Sign 2 Sign 3 Sign 4 Sign 5 Sign 6 Sign N Symptom 1 Symptom 2 Symptom 3 Symptom 4 Symptom 5 Symptom N Neuroscience Cs Disconnection Ci Over connection De-optimization Hyper-optimization Constrain frustration Disturbed DMN

  21. NeuroAnalysis Rational Psychosis Disconnection Syndrome Phenomenology Sign 1 Sign 2 Sign 3 Sign 4 Sign 5 Sign 6 Sign N Symptom 1 Symptom 2 Symptom 3 Symptom 4 Symptom 5 Symptom N Neuroscience Cs Disconnection Ci Over connection De-optimization Hyper-optimization Constrain frustration Disturbed DMN

  22. NeuroAnalysis Rational Phenomenology Sign 1 Sign 2 Sign 3 Sign 4 Sign 5 Sign 6 Sign N Symptom 1 Symptom 2 Symptom 3 Symptom 4 Symptom 5 Symptom N Neuroscience Cs Disconnection Ci Over connection De-optimization Hyper-optimization Constrain frustration Disturbed DMN

  23. NeuroAnalysis Rational Clinical Brain Profiling CBP Phenomenology Sign 1 Sign 2 Sign 3 Sign 4 Sign 5 Sign 6 Sign N Symptom 1 Symptom 2 Symptom 3 Symptom 4 Symptom 5 Symptom N Neuroscience Cs Disconnection Ci Over connection De-optimization Hyper-optimization Constrain frustration Disturbed DMN

  24. NeuroAnalysis Rational Clinical Brain Profiling CBP Based on Literature Publications Based on 20 years of theoretical work Based on Neural network simulations Phenomenology Sign 1 Sign 2 Sign 3 Sign 4 Sign 5 Sign 6 Sign N Symptom 1 Symptom 2 Symptom 3 Symptom 4 Symptom 5 Symptom N Neuroscience Cs Disconnection Ci Over connection De-optimization Hyper-optimization Constrain frustration Disturbed DMN

  25. NeuroAnalysis Rational Clinical Brain Profiling CBP Sign 1 Sign 2 Sign 3 Sign 4 Sign 5 Sign 6 Sign N Symptom 1 Symptom 2 Symptom 3 Symptom 4 Symptom 5 Symptom N Cs Disconnection Ci Over connection De-optimization Hyper-optimization Constrain frustration Disturbed DMN D = 13 Cs =10 Hbu =7 DMN =5 CF =5 Predicted disturbance Ci =3 CF(b) = 2 Htd =1 O =0

  26. NeuroAnalysis Validation

  27. Correct with Pacemaker Cardiac Insufficiency Algorithm of Disturbance Diagnose Algorithm of Disturbance Correct with Brain Pacemaker Diagnose Brain Insufficiency

  28. Correct with Pacemaker Cardiac Insufficiency Algorithm of Disturbance Diagnose Brain disturbance Phenomenology Algorithm of Disturbance Correct with Brain Pacemaker Diagnose Brain Insufficiency

  29. Clinical Brain Profiling CBP Correct with Pacemaker Cardiac Insufficiency Algorithm of Disturbance Diagnose Algorithm of Disturbance Correct with Brain Pacemaker Brain Insufficiency

  30. N E U R O A N A L Y S I S neuroanalysis.org.il

  31. N E U R O A N A L Y S I S neuroanalysis.org.il

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