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Bone Sarcoma Biology: 20 years Later

Bone Sarcoma Biology: 20 years Later. Sarcomas with specific reciprocal translocations. Sarcomas with complex unbalanced karyotypes. Biology. Treatment (Prognostication). Biological Insights/Prognostic Factors. Important to identify and describe, even more critical will be to validate.

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Bone Sarcoma Biology: 20 years Later

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  1. Bone Sarcoma Biology: 20 years Later Sarcomas with specific reciprocal translocations Sarcomas with complex unbalanced karyotypes Biology Treatment (Prognostication)

  2. Biological Insights/Prognostic Factors • Important to identify and describe, even more critical will be to validate. • Three interesting candidates in osteosarcoma presented. • Identified using very different modalities – integrative analysis, deep sequencing, proteomics.

  3. Tadashi Kondo Nalan Gokgoz 53 gene signature for outcome Peroxiredoxin2 correlates with response to induction Leonardo A. Meza-Zepeda RNA and DNA sequencing identified a translocation between chromosome 17 and 6, involving the PMP22 and ELOVL5 genes respectively.

  4. Therapeutic Approaches Francois Lamoureux Ymera Pignochino Inhibition of clusterin with OGX-011 is synergistic with zoledronate in osteosarcoma Trabectidin and PARP-1 inhibition is synergisic

  5. Randomized phase 2 trial in chondrosarcoma – Andrew Wagner • Hedgehog pathway - strong preclinical rationale • Appropriate design and PFS endpoint – challenging disease • The planned biology studies may help understand the trial results further

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