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UDP-GlcNAc as a Metabolic Sensor in O-GlcNAc Transferase Activity

UDP-GlcNAc serves as the key donor substrate for O-GlcNAc transferase (OGT), highlighting its critical role in cellular glycosylation processes. This sugar nucleotide acts as a vital sensor of the cell's metabolic state, influencing various signaling pathways and cellular functions. Understanding the dynamics of UDP-GlcNAc is essential for comprehending its impact on health and disease, particularly in relation to metabolic disorders and cellular signaling mechanisms. This concept is discussed in detail in Chapter 18, Figure 7 of "Essentials of Glycobiology, Second Edition."

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UDP-GlcNAc as a Metabolic Sensor in O-GlcNAc Transferase Activity

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  1. UDP-GlcNAc is the donor for O-GlcNAc transferase (OGT) and an ideal sensor of the metabolic status of the cell Essentials of Glycobiology Chapter 18, Figure 7 Second Edition

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