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TGF- β Receptor II and Gastric Cancer
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  1. TGF-βReceptor II and Gastric Cancer Demi Dabor-Alloh

  2. TGF-β Receptor II is a trans-membrane serine/threonine kinase

  3. TGF β signalling regulates many cell processes • including: • Growth Inhibition • Cell Migration • Invasion • Epithelial – Mesenchymal Transition • Extracellular Matrix Remodelling • Immune - suppression

  4. Knocking out TGF-β receptor II caused embryonic lethality and defects of yolk sac haematopoiesis and vasculogenesis

  5. Gastric cancer is the second most frequent cause of cancer death in the world after lung cancer.

  6. Some patients with gastric cancer have mutations that truncate the TGF-βRII protein

  7. The TGF-βParadox: it has Cytostatic effects vs. tumour favouring effects

  8. Surgery is the primary treatment for gastric cancer Endoscopic Mucosal Resection Total Gastrectomy http://www.hopkins-gi.org

  9. Works Cited Oshima, M., Oshima, H., Taketo, M.M, 1996. TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoesis and Vasculogenesis. Developmental Biology, 179, pp297 – 302. Yang, H.K., Kang S.H., Kim, Y.S., et al, 1999. Truncation of the TGF-β type II receptor gene results in insensitivity to TGF-β in human gastric cancer cells. Oncogene, 18, pp2213 – 2219. Akhurst, R.J., Derynck R, 2001. TGF-βsignilling in cancer – a double-edged sword. Trends in Cell Biology, 11 (11), pp44 – 49. Bachman, K.E., Park, B.H, 2005. Duel nature of TGF-β signalling: tumor suppressor vs. tumor promoter. Current Opinion in Oncology, 17, pp49 – 54. Akhurst, R.J., Hata, A, 2012. Targeting the TGF-β signalling pathway in disease. Nature, 11, pp790 – 807. Narayan, S., Thangasamy, T., Balusu, R, Transforming Growth Factor – Beta Receptor Signalling in Cancer, 2005. Frontiers in Bioscience, 10, pp1135 – 1145. Jakowlew, S, 2006. Transforming growth factor- βin cancer and metastasis. Cancer Metastasis Review, 25, pp435 – 457. Mishra, L., Shetty, K., Tang,Y., et al, 2005. The role of TGF- βand Wntsignaling in gastrointestinal stem cells and cancer. Oncogene, 24, pp5775 – 5789. de Caestecker, M.P., Piek, E., Roberts, A.B, 2000. Role of Transforming Growth Factor-βSignaling in Cancer. Journal of the National Cancer Institute, 92 (1), pp388 – 402. Becker, K.F., Keller, G, 2010. Gastric Cancer, Encyclopaedia of Life Sciences.