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TGF-βReceptor II and Gastric Cancer Demi Dabor-Alloh
TGF β signalling regulates many cell processes • including: • Growth Inhibition • Cell Migration • Invasion • Epithelial – Mesenchymal Transition • Extracellular Matrix Remodelling • Immune - suppression
Knocking out TGF-β receptor II caused embryonic lethality and defects of yolk sac haematopoiesis and vasculogenesis
Gastric cancer is the second most frequent cause of cancer death in the world after lung cancer.
Some patients with gastric cancer have mutations that truncate the TGF-βRII protein
The TGF-βParadox: it has Cytostatic effects vs. tumour favouring effects
Surgery is the primary treatment for gastric cancer Endoscopic Mucosal Resection Total Gastrectomy http://www.hopkins-gi.org
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