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Comparative Sequence Alignment of RNase Z and Metallo-β-Lactamase COGs

This supplementary figure presents the sequence alignment of RNase Z with key COGs from the metallo-β-lactamase family, highlighting their evolutionary relationships and functional similarities. Families include pfam00753, COG0491, COG0595, COG1237, COG1236, COG1235, and COG1234.

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Comparative Sequence Alignment of RNase Z and Metallo-β-Lactamase COGs

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  1. Supplementary Figure 1. Sequence alignment of RNase Z and COGs of the metallo -lactamase family. Families are as follows: pfam00753, Lactamase-, Metallo--lactamase superfamily; COG0491, GloB, Zn-dependent hydrolases, including glyoxylases; COG0595, Predicted hydrolase of the metallo--lactamase superfamily; COG1237, Metal-dependent hydrolases of the -lactamase superfamily II; COG1236, YSH1, Predicted exonuclease of the -lactamase fold involved in RNA processing; COG1235, PhnP, Metal-dependent hydrolases of the -lactamase superfamily I; COG1234, ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III.

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