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Economic evaluation alongside clinical trials: The GALA trial

Economic evaluation alongside clinical trials: The GALA trial. Manuel Gomes, Marta Soares, Jo Dumville, David Torgerson Dep. of Health Sciences - University of York. Why is economic evaluation important?. The objective of the budget holder is to maximise health gains from a fixed budget

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Economic evaluation alongside clinical trials: The GALA trial

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  1. Economic evaluation alongside clinical trials:The GALA trial Manuel Gomes, Marta Soares, Jo Dumville, David Torgerson Dep. of Health Sciences - University of York

  2. Why is economic evaluation important? Theobjectiveof the budget holder is to maximise health gains from a fixed budget There is an opportunity costassociated with each choice Economic evaluationaims to inform decisions about resource allocation - value for money

  3. What is economic evaluation? Comparative analysisof competing interventions with respect to: costs health benefits Characterisation of uncertaintysurrounding the decision Identify and make explicit the set ofcriteriaused for decision making

  4. Main methods for economic evaluation Cost-effectiveness analysis Health benefits measured in natural units: event-free days Cost-utility analysis Health benefits expressed as a single measure combining quality gains (morbidity) and quantity gains (longevity) Quality Adjusted Life Years (QALYs)

  5. Economic evaluation potential results + NE quadrant NW quadrant New intervention is - more costly - more beneficial New intervention is - more costly - less beneficial Differences in cost - + + 0 Differences in effectiveness New intervention is - less costly - less beneficial New intervention is - less costly - more beneficial SW quadrant SE quadrant -

  6. The GALA Trial Preliminary Economic Analysis Cost effectiveness analysis RCT based Perspective – health care provider Time horizon – 1 year Health outcome Event free survival (MI, stroke, death) Relevant resources

  7. The GALA TrialUnit Costs

  8. The GALA TrialResource Use

  9. The GALA TrialPreliminary Cost Estimation * LA minus GA ϮStandardt-tests

  10. The GALA TrialEllipse Curves

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