1 / 38

Signal-transduction pathways: an introduction to information metabolism

Signal-transduction pathways: an introduction to information metabolism. Signal Transduction Depends on Molecular Circuits: An Overview. Signal Transduction Depends on Molecular Circuits: An Overview. Membrane receptors transfer information from the environment to the cell's interior

dylanr
Télécharger la présentation

Signal-transduction pathways: an introduction to information metabolism

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Signal-transduction pathways: an introduction to information metabolism

  2. Signal Transduction Depends on Molecular Circuits: An Overview

  3. Signal Transduction Depends on Molecular Circuits: An Overview • Membrane receptors transfer information from the environment to the cell's interior • 2. Second messengers relay information from the receptor-ligand complex • 3. Protein phosphorylation is a common means of information transfer • 4. The signal is terminated

  4. Signal Transduction Depends on Molecular Circuits: An Overview

  5. Signal Transduction Depends on Molecular Circuits: An Overview

  6. Signal Transduction Depends on Molecular Circuits: An Overview

  7. Seven-Transmembrane-Helix Receptors Change Conformation in Response to Ligand Binding and Activate G Proteins

  8. Seven-Transmembrane-Helix Receptors Change Conformation in Response to Ligand Binding and Activate G Proteins

  9. Seven-Transmembrane-Helix Receptors Change Conformation in Response to Ligand Binding and Activate G Proteins

  10. Seven-Transmembrane-Helix Receptors Change Conformation in Response to Ligand Binding and Activate G Proteins

  11. Seven-Transmembrane-Helix Receptors Change Conformation in Response to Ligand Binding and Activate G Proteins

  12. Activated G Proteins Transmit Signals by Binding to Other Proteins

  13. Activated G Proteins Transmit Signals by Binding to Other Proteins

  14. G Proteins Spontaneously Reset Themselves Through GTP Hydrolysis

  15. Cyclic AMP Stimulates the Phosphorylation of Many Target Proteins by Activating Protein Kinase A

  16. Seven-Transmembrane-Helix Receptors Change Conformation in Response to Ligand Binding and Activate G Proteins

  17. The Hydrolysis of PhosphatidylInositolBisphosphate by Phospholipase C Generates Two Messengers

  18. Modular Structure of Phospholipase C

  19. Modular Structure of Phospholipase C

  20. Inositol 1,4,5-trisphosphate Opens Channels to Release Calcium Ions from Intracellular Stores Calcium Ion Is a Ubiquitous Cytosolic Messenger

  21. Inositol 1,4,5-trisphosphate Opens Channels to Release Calcium Ions from Intracellular Stores Calcium Ion Is a Ubiquitous Cytosolic Messenger

  22. Inositol 1,4,5-trisphosphate Opens Channels to Release Calcium Ions from Intracellular Stores Calcium Ion Is a Ubiquitous Cytosolic Messenger

  23. Diacylglycerol Activates Protein Kinase C, Which Phosphorylates Many Target Proteins

  24. Metabolism of Diacylglycerol

  25. Some Receptors Dimerize in Response to Ligand Binding and Signal by Crossphosphorylation

  26. Some Receptors Dimerize in Response to Ligand Binding and Signal by Crossphosphorylation

  27. Phosphorylation-Induced Dimerization of STAT Proteins

  28. Ras superfamily of GTPases

  29. Some Receptors Dimerize in Response to Ligand Binding and Signal by Crossphosphorylation

  30. Structure of Sos, a Guanine-Nucleotide Exchange Factor

  31. Defects in Signaling Pathways Can Lead to Cancer and Other Diseases

  32. Defects in Signaling Pathways Can Lead to Cancer and Other Diseases

  33. Cholera and Whooping Cough Are Due to Altered G-Protein Activity

More Related