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Receptors and signal transduction in the ANS

Receptors and signal transduction in the ANS. Cholinergic Receptors. Nicotinic. Muscarinic. Ganglionic. Skeletal Muscle. Neuronal CNS. Receptors and signal transduction in the ANS: Nicotinic Receptors. g. d. a. a. b.

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Receptors and signal transduction in the ANS

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  1. Receptors and signal transduction in the ANS Cholinergic Receptors Nicotinic Muscarinic Ganglionic Skeletal Muscle Neuronal CNS

  2. Receptors and signal transduction in the ANS: Nicotinic Receptors

  3. g d a a b Receptors and signal transduction in the ANS: Nicotinic Receptors

  4. Receptors and signal transduction in the ANS Cholinergic Receptors Nicotinic Muscarinic M1 M3 M5 M2 M4

  5. Receptors and signal transduction in the ANS: Muscarinic receptors are 7 transmembrane domain, G-protein coupled receptors

  6. Receptors and signal transduction in the ANS: Muscarinic receptors(M1, M3, M5) NH 3 Phospho - (+) G lipase C q PIP 2 IP Diacylglycerol COOH 3 2+ Increase Ca Activate Protein Kinase C Response

  7. Receptors and signal transduction in the ANS: Muscarinic Receptors (M2 and M4)

  8. a1 a2 b a1B a1D a2A a2B a2C b1 b2 Receptors and signal transduction in the ANS Adrenergic Receptors a1A b3

  9. Receptors and signal transduction in the ANS: a1-AdrenergicReceptors

  10. Receptors and signal transduction in the ANS: a2-AdrenergicReceptors

  11. Receptors and signal transduction in the ANS: b-AdrenergicReceptors

  12. b 1 b 1, Functional Responses Mediated by the ANS Adrenergic Cholinergic Effector Organ Response Receptor Response Receptor Heart Rate of Contraction Increase Decrease M 2 Force of Contraction Increase Decrease M 2

  13. Functional Responses Mediated by the ANS Adrenergic Cholinergic Effector Organ Response Receptor Response Receptor a Arteries (most) Vasoconstriction ---------- -- 1 a Veins Vasoconstriction ---------- -- 2 b Skeletal Muscle Vasodilation ---------- -- 2 Endothelium ---------- -- Release EDRF M 3

  14. b 2 Functional Responses Mediated by the ANS Adrenergic Cholinergic Effector Organ Response Receptor Response Receptor Lung Bronchiolar smooth muscle Bronchodilation Bronchoconstriction M3

  15. a a 1 1 Functional Responses Mediated by the ANS Adrenergic Cholinergic Effector Organ Response Receptor Response Receptor Genitourinary, smooth muscle b2 Bladder wall Relaxation Contraction M3 a Ureter Contraction Relaxation M3 1 a Sphincter Contraction Relaxation M3 1 Uterus (pregnant) Relaxation b2 Variable Contraction M 3 Erection Penis/vas deferens Ejaculation M3

  16. a 1 M M 3 3 Functional Responses Mediated by the ANS Adrenergic Cholinergic Effector Organ Response Receptor Response Receptor Gastrointestinal Tract Salivary Glands Increase secretion Increase secretion Smooth Muscle: a b Walls Contraction Relaxation M3 , 2 2 a Sphincters Contraction Relaxation M3 1 Secretion ---------- -- Increase secretion

  17. Functional Responses Mediated by the ANS Adrenergic Cholinergic Effector Organ Response Receptor Response Receptor Skin a1 Hair follicles, Smooth muscle Contraction, Piloerection -------------- -- Sweat glands -------------- M3 Thermoregulation Increase secretion -- -------------- a1 Apocrine (stress) Increase secretion --

  18. Functional Responses Mediated by the ANS Adrenergic Cholinergic Effector Organ Response Receptor Response Receptor Eye Iris -------------- a1 Radial muscle Contraction -- Contraction -- Circular muscle ------------- M3 Contraction b2] [Relaxation Ciliary muscle M3 -------------- b2 Increase secretion of aqueous humor Ciliary epithelium --

  19. Physiology of the eye Cornea Canal of Schlemm Trabecular meshwork Circular muscle (M3) Radial muscle (a1) Sclera Iris Lens Ciliary muscle (M3) Ciliary epithelium (b2)

  20. Physiology of the eye

  21. Physiology of the eye Circular muscle (M3 Receptors) Pupil

  22. Physiology of the eye Contraction of circular muscle leads to miosis Pupil

  23. Physiology of the eye Contraction of circular muscle leads to miosis Pupil

  24. Physiology of the eye Radial Muscle ( a1 Receptors) Pupil

  25. Physiology of the eye Contraction of radial muscle leads to mydriasis Pupil

  26. Functional Responses Mediated by the ANS Adrenergic Cholinergic Effector Organ Response Receptor Response Receptor Metabolic functions a1,b2 Liver Glycogenolysis -------------- -- Gluconeogenesis b1,b3 Fat cells Lipolysis -------------- -- b Kidney -------------- -- Increase renin secretion 1 -------------- Pancreas a2 Decrease insulin release --

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