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Understanding Antiemetic Medications for Managing Nausea and Vomiting: A Comprehensive Guide

This guide delves into the use of various drugs like benzodiazepines, steroids, levomepromazine, cyclizine, and more to combat nausea and vomiting caused by different triggers. Learn about how these medications target specific receptors in the cortical structures and the autonomic nervous system.

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Understanding Antiemetic Medications for Managing Nausea and Vomiting: A Comprehensive Guide

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  1. Cortical structures eg pain, fear, sights, smells, raised ICP: Benzodiazepines & steroids ?GABA Vomiting centre levomepromazine Hyoscine Cyclizine* M H1 5-HT2 Vestibular Apparatus Levomepromazine Cyclizine* Hyoscine Chemoreceptor trigger zone (CTZ) eg drugs, toxins, biochemical upset Haloperidol* Metoclopramide Levomepromazine H1 M D25-HT3M Autonomic nervous system (vagus nerve) eg pharyngeal irritation, gastric/bowel obstruction, constipation Levomepromazine Metoclopramide* Ondansetron N&V Key: Site Cause Antiemetic [Highest receptor affinity top] [*usual first line] J Adam 2006 M D2 5-HT3 Receptors

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