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The Role of S-Phase Driven dNTP Demand in DNA Damage and Mismatch Repair in Cancer

This article explores the significance of dNTP demand during the S-phase of the cell cycle, focusing on how it influences DNA damage repair mechanisms, particularly in defective cancers. It examines the utilization of IUdR salvage pathways and the role of IdUTP in DNA synthesis and repair. The study emphasizes the importance of efficient mismatch repair systems in maintaining genomic stability and highlights potential therapeutic strategies targeting these pathways in cancer therapy.

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The Role of S-Phase Driven dNTP Demand in DNA Damage and Mismatch Repair in Cancer

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  1. DNA damage driven or S-phase driven dNTP demand is either IUdR salvage dNTPs + IdUTP DNA + IU-DNA de novo focus on mismatch repair defective cancers DNA repair

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