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Electrophysiology Subject Specific Models

Electrophysiology Subject Specific Models. Darrell Swenson Scientific Computing and Imaging (SCI) Institute Cardiovascular Research and Training Institute (CVRTI) Department of Bioengineering Dr. Rob MacLeod. Cardiac Ischemia. Hearts are electrical organs

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Electrophysiology Subject Specific Models

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  1. Electrophysiology Subject Specific Models Darrell Swenson Scientific Computing and Imaging (SCI) Institute Cardiovascular Research and Training Institute (CVRTI) Department of Bioengineering Dr. Rob MacLeod

  2. Cardiac Ischemia • Hearts are electrical organs • Electrical current causes heart contraction • Most heart failures are electrical • ECG’s show hearts electrical activity • Coronary Arteries supply blood to the heart. • Coronary blood flow provides the needed nutrients and ions • Conduction rate is dependent on blood flow.

  3. Cardiac Ischemia • Ischemia is the lack of blood flow • The lack of blood flow changes the conductance. • Changes in conductance alter the activation wave. • This often leads to heart failure • These changes can be detected with an ECG • ECGs are insufficient to detect a large percentage of ischemia. • Comparable ischemic regions produce dramatically different ECG signals. • The cause could be Individual structure variability.

  4. Subject Specific Modeling Problem Specific Models • Dynamic ischemic zone that changes based on experimental data. • Adaptive meshing based on fiber directions • Variable myocardial wall thickness Subject Specific Geometry • Shape of heart • Shape and time point of the ischemic region • Fiber orientation for anisotropic conduction

  5. MRI Segmentation Surface Meshing 3D Meshing DTI Surface Potentials MRI • Small animal imaging facility • 7 tesla scanner • High resolution and DTI scans • Gd markers used for registration

  6. MRI Segmentation Surfacing Meshing DTI Surface Potentials

  7. Segmentation Surface Meshing MRI 3D Meshing DTI Surface Potentials Segmentation • Seg3D • Segment myocardium and ischemic region • Each segmentation requires a small amount of manual editing

  8. Surface Meshing MRI Segmentation 3D Meshing DTI Surface Potentials Marching Cubes • SCIRun implementation • Smoothed with fairmesh algorithm • ~400,000 tris elements • Very detailed Particle System • Uses tetgen for surface • Not currently in SCIRun • Very detailed

  9. Surface Meshing MRI Segmentation 3D Meshing DTI Surface Potentials

  10. 3D Meshing MRI Segmentation Surface Meshing DTI Surface Potentials Meshing • 1,400,000 Elements • Tetgen used for both marching cubes and particle system surfaces

  11. 3D Meshing MRI Segmentation Surface Meshing DTI Surface Potentials

  12. DTI MRI Segmentation Surface Meshing 3D Meshing Surface Potentials Fiber Direction • Diffusion tensor imaging (DTI) • Anisotropic properties • Tensor interpolation

  13. Surface Potentials MRI Segmentation Surface Meshing 3D Meshing DTI Ischemic Model • Bidomain model • Interactively adaptable ischemic zone • Segmented ischemic zones • Correlates to experimental results

  14. Surface Potentials MRI Segmentation Surface Meshing 3D Meshing DTI Ischemic Model • Bidomain model • Interactively move ischemic zone • Segment ischemic zones • Correlate to lab results

  15. Thanks!

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