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This study explores how disrupting the signaling pathways in the interpeduncular nucleus (IPN) or medial habenula (MHb) impact nicotine intake in rats. Findings suggest that alterations in these pathways can lead to increased nicotine consumption.
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Disruption of IPN or MHb signalling increases nicotine intake in rats. CD Fowler et al.Nature000, 1-5 (2010) doi:10.1038/nature09797