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Ledipasvir-sofosbuvir +/- 3 rd DAA in HCV Genotype 1 NIH SYNERGY

Phase 2. Treatment Naïve (unfavorable baseline treatment characteristics). Ledipasvir-sofosbuvir +/- 3 rd DAA in HCV Genotype 1 NIH SYNERGY. Kohli A, et al. 21 st CROI. 2014:Abstract 27LB. . Sofosbuvir-Ledipasvir +/- GS-9669 or GS-9451 in Naïve GT1 NIH SYNERGY Trial : Features.

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Ledipasvir-sofosbuvir +/- 3 rd DAA in HCV Genotype 1 NIH SYNERGY

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  1. Phase 2 TreatmentNaïve (unfavorable baseline treatment characteristics) Ledipasvir-sofosbuvir +/- 3rd DAA in HCV Genotype 1 NIH SYNERGY KohliA, et al. 21st CROI. 2014:Abstract 27LB.

  2. Sofosbuvir-Ledipasvir +/- GS-9669 or GS-9451 in Naïve GT1NIH SYNERGY Trial: Features Source: Kohli A, et al. 21st CROI. 2014:Abstract 27LB.

  3. Sofosbuvir-Ledipasvir +/- GS-9669 or GS-9451 in Naïve GT1NIH SYNERGY Trial: Participants Source: Kohli A, et al. 21st CROI. 2014:Abstract 27LB.

  4. Sofosbuvir-Ledipasvir +/- GS-9669 or GS-9451 in Naïve GT1NIH SYNERGY Trial: Features 0 6 12 Week Treatment NaïveAll stages fibrosis Ledipasvir + Sofosbuvir n =20 SVR12 Treatment NaïveCirrhosis excluded Ledipasvir + Sofosbuvir + GS-9669 n = 20 SVR12 Treatment NaïveCirrhosis excluded Ledipasvir + Sofosbuvir + GS-9451 n = 20 SVR12 Drug Classes/MechanismLedipasvir (investigational): NS5A inhibitorSofosbuvir: nucleotide NS5B polymerase inhibitor GS-9669 (investigational): non-nucleoside NS5B inhibitorGS-9451 (investigational): NS3/4 protease inhibitor Drug DosingLedipasvir-Sofosbuvir: 90/400 mg fixed dose combination one pill once dailyGS-9669: 500 mg once dailyGS-9451: 80 mg once daily Source: Kohli A, et al. 21st CROI. 2014:Abstract 27LB.

  5. Sofosbuvir-Ledipasvir +/- GS-9669 or GS-9451 in Naïve GT1NIH SYNERGY Trial: Features NIH SYNERGY: SVR 12 by Treatment Regimen 20/20 19/20 20/20 Source: Kohli A, et al. 21st CROI. 2014:Abstract 27LB.

  6. This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects. Hepatitis C Onlinewww.hepatitisc.uw.edu Hepatitis Web Studyhttp://depts.washington.edu/hepstudy/ Funded by a grant from the Centers for Disease Control and Prevention.

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