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Investigating the Impact of Dacetuzumab Crosslinking on Cell Death and Proliferation Pathways in Ramos Cells

This study delves into the effects of crosslinked dacetuzumab on cell death (apoptotic and necrotic) and proliferation in Ramos cells. The research explores the signaling cascades involving phospho-ERK1/2, phospho-p38 MAPK, IkB-a, and phospho-AKT. The experiment also examines CD40 Ligand and hIgG interactions with dacetuzumab to uncover potential mechanisms underlying cellular responses. Findings are presented in Supplementary Figure 1 by Lewis et al.

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Investigating the Impact of Dacetuzumab Crosslinking on Cell Death and Proliferation Pathways in Ramos Cells

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  1. Cell Death (Ramos) Untreated Proliferation (Ramos) hIgG (crosslinked) Dacetuzumab (soluble) Dacetuzumab (crosslinked) Percent Cell Death (apoptotic + necrotic) Crosslinking Ab Dacetuzumab (soluble) hIgG (crosslinked) Dacetuzumab (crosslinked) CD40 Ligand hIgG (soluble) Untreated mg/ml 1 3 10 1 3 10 10 10 20 1 ng/ml phospho-ERK1/2 MAPK Dacetuzumab (crosslinked) phospho-p38 MAPK IkB-a Dacetuzumab phospho-AKT Untreated 1.00x103 Lane: 1 2 3 4 5 6 7 8 9 10 11 4.12 12.3 37.0 111 333 ng/ml phospho-ERK1/2 MAPK b-Actin Ramos a Dacetuzumab Signaling (RL) b c Supplementary Figure 1 Lewis, et al.

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